Results 191 to 200 of about 3,071,772 (281)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Investigating low uptake of tuberculin skin testing when integrated with active case-finding for TB. [PDF]

IJTLD Open
Johnson TS, Nalutaaya A, Biché P, Ndyabayunga K, Okura R, Mugabi I, Nantale D, Nakiiza V, Kitonsa PJ, Kendall EA, Katamba A, Dowdy DW.   +11 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Implementation costs and cost-effectiveness of ultraportable chest X-ray with artificial intelligence in active case finding for tuberculosis in Nigeria. [PDF]

PLOS Digit Health
Garg T, John S, Abdulkarim S, Ahmed AD, Kirubi B, Rahman MT, Ubochioma E, Creswell J.   +7 more
europepmc   +1 more source

Quantifying the potential epidemiological impact of a 2-year active case finding for tuberculosis in rural Nepal: a model-based analysis. [PDF]

BMJ Open, 2023
Shrestha S, Mishra G, Hamal M, Dhital R, Shrestha S, Shrestha A, Shah NP, Khanal M, Gurung S, Caws M.   +9 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Operational feasibility of the ultra-portable digital X-rays with Computer-Aided Detection (CAD) for community active case finding for TB in Nigeria: Health care workers and client's perspectives. [PDF]

PLOS Glob Public Health
Useni S, Eneogu R, Ihesie A, Alege A, Agbaje A, Odume B, Nongo D, Chukwu E, Olabamiji J, Oyelaran O, Ohikhuai C, Qin ZZ, Barrett R, Omosebi O, Anyaike C, Ewa A.   +15 more
europepmc   +1 more source

Impact of active case-finding for tuberculosis on case-notifications in Blantyre, Malawi: A community-based cluster-randomised trial (SCALE). [PDF]

PLOS Glob Public Health, 2023
Feasey HRA, Khundi M, Soko RN, Bottomley C, Chiume L, Burchett HED, Nliwasa M, Twabi HH, Mpunga JA, MacPherson P, Corbett EL.   +10 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Active Case Finding (ACF) of Tuberculosis Among School Students: Insights From a Tribal District in Seoni, Madhya Pradesh, India. [PDF]

Cureus
Sharma Y, Bhatia M, Dwivedi V, Mitra B, Sabharwal V, Rai V.   +5 more
europepmc   +1 more source