Results 211 to 220 of about 783,140 (262)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Community views on active case finding for tuberculosis in low- and middle-income countries: a qualitative evidence synthesis. [PDF]

Cochrane Database Syst Rev
Taylor M, Medley N, van Wyk SS, Oliver S.   +3 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Effectiveness of Using AI-Driven Hotspot Mapping for Active Case Finding of Tuberculosis in Southwestern Nigeria. [PDF]

Trop Med Infect Dis
Alege A, Hashmi S, Eneogu R, Meurrens V, Budts AL, Pedro M, Daniel O, Idogho O, Ihesie A, Potgieter MG, Akaniro OC, Oyelaran O, Charles MO, Agbaje A.   +13 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Quantifying sputum production success during community-based screening for TB

IJTLD Open
P.J Kitonsa, J. Sung, D. Isooba, S. Birabwa, I. Naluyima, J. Kakeeto, W. Kamya, A. Nalutaaya, P. Biché, D.W. Dowdy, A. Katamba, E.A. Kendall   +11 more
doaj   +1 more source

Active case finding to detect symptomatic and subclinical pulmonary tuberculosis disease: implementation of computer-aided detection for chest radiography in Viet Nam. [PDF]

Western Pac Surveill Response J
Innes AL, Martinez A, Hoang GL, Nguyen TBP, Vu VH, Luu THT, Le TTT, Lebrun V, Trieu VC, Tran NDB, Dinh N, Pham HM, Dinh VL, Nguyen BH, Truong TTH, Nguyen VC, Nguyen VN, Mai TH.   +17 more
europepmc   +1 more source

Enhanced active case finding of drug-resistant tuberculosis in Namibia: a protocol for the hotspots, hospitals, and households (H3TB) study. [PDF]

BMJ Open
Shavuka O, Iipumbu E, Boois L, Günther G, Hoddinott G, Lin HH, Nepolo E, Niemann S, Ruswa N, Seddon J, Claassens MM.   +10 more
europepmc   +1 more source

Active case finding using mobile vans with artificial intelligence aided radiology tests and sputum collection for rapid diagnostic tests to reduce tuberculosis prevalence among high-risk population in rural China: Protocol for a pragmatic trial. [PDF]

PLoS One
Wei X, Liang D, Zhang Z, Thorpe KE, Zhou L, Zhao J, Qin H, Liang X, Cui Z, Huang Y, Huang L, Lin M.   +11 more
europepmc   +1 more source