Results 71 to 80 of about 783,140 (262)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Burden and Associated Factors of Tuberculosis Among Household Contacts of Sputum Positive Tuberculosis Patients of Aligarh

Indian Journal of Community Medicine
Background: Engaging patients in healthcare for diagnosis and treatment through active case-finding, which is initiated by healthcare providers, involves methodically searching for tuberculosis in individuals who may not seek medical attention otherwise.
Simon Jude, Ali J. Abedi, Saira Mehnaz, Mohammad Shameem   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Evaluation of facility and community-based active household tuberculosis contact investigation in Ethiopia: a cross-sectional study

BMC Health Services Research, 2019
Background No established strategy for household tuberculosis (TB) contact investigation (HTCI) exists in Ethiopia. We implemented integrated, active HTCI model into two hospitals and surrounding community health services to determine yield of active ...
Fana Tefera, Gena Barnabee, Anjali Sharma, Beniam Feleke, Daniel Atnafu, Negasi Haymanot, Gabrielle O’Malley, Getachew Feleke   +7 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Prevalence of HIV in a Prison of Tehran by Active Case Finding.

Iranian journal of public health, 2017
Prevalence of HIV in a Prison of Tehran by Active Case ...
Seyed Ahmad SEYEDALINAGHI, Behnam FARHOUDI, Minoo MOHRAZ, Mona MOHAMMADI FIROUZEH, Mostafa HOSSEINI, Kianoush KAMALI   +5 more
openaire   +2 more sources

Status of Tuberculosis services in Indian Prisons

International Journal of Infectious Diseases, 2017
Introduction: Prisons are known to be a high risk environment for tuberculosis (TB) due to overcrowding, low levels of nutrition, poor infection control and lack of accessible healthcare services.
Banuru Muralidhara Prasad, Badri Thapa, Sarabjit Singh Chadha, Anand Das, Entoor Ramachandra Babu, Subrat Mohanty, Sripriya Pandurangan, Jamhoih Tonsing   +7 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Reaching the underserved: Active tuberculosis case finding in urban slums in southeastern Nigeria

International Journal of Mycobacteriology, 2015
Background: Nigeria ranks 10th among 22 high TB burden countries with low TB case detection that relies on passive case finding. Although there is increasing body of evidence that active case finding (ACF) has improved TB case finding in urban slums in ...
Chidubem L Ogbudebe, Joseph N Chukwu, Charles C Nwafor, Anthony O Meka, Ngozi Ekeke, Nelson O Madichie, Moses C Anyim, Chijioke Osakwe, Ugochukwu Onyeonoro, Kingsley N Ukwaja, Daniel C Oshi   +10 more
doaj   +1 more source