Results 61 to 70 of about 14,005,924 (265)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Prevalence of Tuberculosis among Household Contacts in Pondicherry: Active Case Finding Among New Smear Positive Cases

Online Journal of Health & Allied Sciences, 2016
Introduction: The risk of transmission from the index case to its contacts is more in case of smear positive Pulmonary Tuberculosis cases. Any delay in diagnosis and treatment increases the risk of disease transmission to their contacts.
Kumar VA, Kalaiselvan G, Dongre AR
doaj  

ANALYSIS OF COMMUNITY HEALTH VOLUNTEER (CHV) BEHAVIOR IN DETECTING PRESUMPTIVE PULMONARY TB IN BANJARNEGARA

Jurnal Berkala Epidemiologi
Background: Pulmonary TB case detection in Banjarnegara Regency from 202 to 2023 has fallen short of the target. As of June 2024, only 21% of suspected pulmonary TB cases have been identified.
Saroh Saroh, Bagoes Widjanarko, Zahroh Shaluhiyah   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Burden and Associated Factors of Tuberculosis Among Household Contacts of Sputum Positive Tuberculosis Patients of Aligarh

Indian Journal of Community Medicine
Background: Engaging patients in healthcare for diagnosis and treatment through active case-finding, which is initiated by healthcare providers, involves methodically searching for tuberculosis in individuals who may not seek medical attention otherwise.
Simon Jude, Ali J. Abedi, Saira Mehnaz, Mohammad Shameem   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Evaluation of facility and community-based active household tuberculosis contact investigation in Ethiopia: a cross-sectional study

BMC Health Services Research, 2019
Background No established strategy for household tuberculosis (TB) contact investigation (HTCI) exists in Ethiopia. We implemented integrated, active HTCI model into two hospitals and surrounding community health services to determine yield of active ...
Fana Tefera, Gena Barnabee, Anjali Sharma, Beniam Feleke, Daniel Atnafu, Negasi Haymanot, Gabrielle O’Malley, Getachew Feleke   +7 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

What’s new in TB diagnosis? A spotlight on active case-finding

South African Medical Journal
Tuberculosis (TB) remains the deadliest infectious disease globally, with gaps in case detection hindering its control. Active case-finding (ACF) comprises active screening of at-risk populations, including asymptomatic individuals, who constitute ...
A J Scott, T Perumal, S Oelofse, A Esmail, K Dheda   +4 more
doaj   +1 more source