Results 71 to 80 of about 44,169 (308)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A Snake Model Driven by Dynamic Local Data

Mathematics
There are several drawbacks in the existing localization (active contour) models. Some models have poor capability of handling uneven illuminations and low contrasts, others are sensitive to initial condition, and there are still some models which can ...
Qiang Li, Ming Yang
doaj   +1 more source

Fast methods for implicit active contour models

, 2002
Implicit active contour models belong to the most popular level set methods in computer vision. Typical implementations, however, suffer from poor efficiency. In this paper we survey an efficient algorithm that is based on an additive operator splitting (
Weickert, Joachim, Kühne, Gerald
core   +1 more source

Achieving the Way for Automated Segmentation of Nuclei in Cancer Tissue Images through Morphology-Based Approach: a Quantitative Evaluation [PDF]

, 2010
In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for cancer diagnosis and therapy.
MACII E., Ficarra, Elisa, Acquaviva, Andrea, Macii, E., Di Cataldo, Santa   +4 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The multichannel integration active contour framework for crack detection

International Journal of Advanced Robotic Systems, 2019
Crack is one of the most important defects to evaluate the health of concrete buildings. Hence, accurate detection is of great significance for the infrastructure maintenance.
Xiaomin Xie, Yilin Xia, Bo Liu, Kui Li, Tingting Wang   +4 more
doaj   +1 more source

Deep learning base active contour algorithms for diabetic retinopathy segmentation

, 2022
Active contour is one of successful image segmentation techniques, which has been implemented in a wide range of medical imaging problems. Active contour minimizes an energy functional in an unsupervised manner, which offers the required force to ...
Thakkar, Raghavkumar
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Applying Evolution Strategies for Chest Radiographs Segmentation [PDF]

Computer Science Journal of Moldova, 2006
WSegmentation is one of the key areas in computer vision. Advanced techniques, such as active contour models and active shape models suffer from many drawbacks. An improvement of the two approaches, based in evolution strategies, is presented.
Oliviu Matei
doaj