Results 91 to 100 of about 4,733,293 (337)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Reinforcement learned adversarial agent (ReLAA) for active fault detection and prediction in space habitats. [PDF]

NPJ Microgravity, 2023
Overlin M, Iannucci S, Wilkins B, McBain A, Provancher J.   +4 more
europepmc   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Editorial: Understanding the marginal seas of northeast asia for tectonics and submarine geohazards

Frontiers in Earth Science, 2022
Kwang-Hee Kim, Han-Joon Kim, Tianyao Hao, Tianyao Hao, Tianyao Hao, Xunhua Zhang   +5 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Morphological analysis of volcanic cones and its implication to Quaternary tectonics of the Jeju Island (South Korea)

Quaternary Science Advances
The morphological characteristics and distribution of volcanic cones of Jeju Island in Korea could be controlled by several factors, including stress field in the substrate and subsurface fractures. Controlling fractures, however, might not be visible on
Francois Hategekimana, Sambit Prasanajit Naik, Young-Seog Kim   +2 more
doaj  

Active fault-tolerant anti-input saturation control of a cross-domain robot based on a human decision search algorithm and RBFNN. [PDF]

Front Neurorobot, 2023
Wang K, Liu Y, Huang C.
europepmc   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Structural analysis and neotectonic evidences of the dip-slip transverse fault system in the central Mainland Kachchh region, Western India

Quaternary Science Advances
The spatio-temporal changes in the fluvial system and landform of the central Kachchh Mainland region are caused by distinctive ongoing tectonic deformations.
Gaurav Chauhan, Chirag Jani, Girish Ch Kothyari, Siddharth Prizomwala, Chintan Vedpathak, Abhishek Lakhote, Raj Sunil Kandregula, Jaymeet Solanki, Chirag Parmar, Subhash Bhandari, M.G. Thakkar   +10 more
doaj