Results 71 to 80 of about 4,733,293 (337)

Active faulting in the Walker Lane [PDF]

open access: yesTectonics, 2005
Deformation across the San Andreas and Walker Lane fault systems accounts for most relative Pacific–North American transform plate motion. The Walker Lane is composed of discontinuous sets of right‐slip faults that are located to the east and strike approximately parallel to the San Andreas fault system.
openaire   +2 more sources

The cytochrome oxidase defect in ISC‐depleted yeast is caused by impaired iron–sulfur cluster maturation of the mitoribosome assembly factor Rsm22

open access: yesFEBS Letters, EarlyView.
The yeast mitoribosome assembly factor Rsm22 contains a [4Fe‐4S] cluster that is matured by the mitochondrial iron–sulfur cluster assembly (ISC) machinery. Defects in ISC components result in impaired mitochondrial protein synthesis due to a mitoribosome assembly defect.
Ulrich Mühlenhoff   +4 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Updating active fault maps and sliprates along the Sumatran Fault Zone, Indonesia

open access: yes, 2018
The accuracy of active fault map, slip rate and its seismic parameters is crucial for seismic hazard analysis. Fault maps, segmentations and slip rates of the Sumatran Fault Zone (SFZ) have been revised in relation with ongoing activities for updating ...
D. Natawidjaja
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Active Fault Diagnosis on a Hydraulic Pitch System Based on Frequency-Domain Identification

open access: yesIEEE Transactions on Control Systems Technology, 2019
The blade pitch system is a critical subsystem of variable-speed variable-pitch wind turbines that is characterized by a high failure rate. This paper addresses the fault detection and isolation (FDI) of a blade pitch system with hydraulic actuators ...
Sandra Vásquez   +2 more
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Tectonic Geomorphology and Quaternary Activity Characteristics of the Jining River Northern Margin Fault, Inner Mongolia, North China

open access: yesApplied Sciences
The Jining River northern margin fault is a newly discovered Quaternary active fault, located at the junction of the northeastern corner of the Ordos Block and the Yinshan-Yanshan Uplift (Jining District, Ulanqab, Inner Mongolia). The northeastern margin
Haowen Ma, Shaopeng Dong
doaj   +1 more source

Active Faults in Iberia [PDF]

open access: yes, 2019
Peer ...
Sanz de Galdeano, Carlos   +22 more
openaire   +4 more sources

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