Results 151 to 160 of about 34,009 (308)

Tectonic evolution of the Corinth Rift

, 2008
The evolution of extensional processes at continental rift zones provides important constraints on the underlying lithospheric deformation mechanisms, level of seismic hazard and location of likely hydrocarbon traps. The Corinth rift in central Greece is
Bell, Rebecca E., Bell, Rebecca E
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Train Traffic as a Powerful Noise Source for Monitoring Active Faults With Seismic Interferometry. [PDF]

Geophys Res Lett, 2019
Brenguier F, Boué P, Ben-Zion Y, Vernon F, Johnson CW, Mordret A, Coutant O, Share PE, Beaucé E, Hollis D, Lecocq T.   +10 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Active Faults Surveys in the Ise Bay

, 2000
Hydrographic department carried out the seismic reflection surveys for the purpose of define the distributions of buried active faults and morphology of the basement in the Ise bay.
Kawajiri, Chitoshi, Noda, Naoki, Amma, Kei, Kato, Isao, Kadoya, Naoya, Aoto, Sumio, Nagata, Satoshi, Iwabuchi, Yo, Nishikawa, Hiroshi, Nakagawa, Masanori   +9 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Physical modeling of normal faults and graben relays above salt

, 2002
textIn salt basins, thin-skinned extension is typically accommodated by graben development in sedimentary overburden and viscous flow in the evaporitic layer.
Le Calvez, Joel Herve
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Unraveling the Connection Between Subsurface Stress and Geomorphic Features

Geophysical Research Letters
The tectonic stress field induces surface deformation. At long wavelengths, both lithospheric heterogeneity (changes in the thickness and density of crust and lithospheric mantle) and basal tractions from mantle convection contribute to the stress field.
B. Kuhasubpasin, S. Moon, C. Lithgow‐Bertelloni   +2 more
doaj   +1 more source