Results 141 to 150 of about 34,009 (308)
Mapping fault geomorphology with drone-based lidar
SeismicaThe advent of sub-meter resolution topographic surveying has revolutionized active fault mapping. Light detection and ranging (lidar) collected using crewed airborne laser scanning (ALS) can provide ground coverage of entire fault systems but is ...
Guy Salomon +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
TECTONOPHYSICAL ZONING OF THE TIEN SHAN ACTIVE FAULTS – DETERMINISTIC STRONG EARTHQUAKE PREDICTION
Геодинамика и тектонофизикаThe January 23, 2024 М7.0 Wushi earthquake (China) put an end to the period of strong earthquake quiescence that had lasted for about 33 years in the Tien Shan. The risk of occurrence of new strong earthquakes in the coming years has been discussed among
K. E. Abdrakhmatov +16 more
doaj +1 more source
Mechanics of continental extension from Quaternary strain fields in the Italian Apennines
, 2010 Horizontal upper crustal surface strain-rates calculated using slip-vectors from striated faults and offsets of Late Pleistocene-Holocene landforms and sediments are used to investigate the mechanisms responsible for deformation in the Italian Apennines ...
Faure Walker, J. P.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Bayesian Diagnosability and Active Fault Identification
2025 IEEE 64th Conference on Decision and Control (CDC)We study fault identification in discrete-time nonlinear systems subject to additive Gaussian white noise. We introduce a Bayesian framework that explicitly accounts for unmodeled faults under reasonable assumptions. Our approach hinges on a new quantitative diagnosability definition, revealing when passive fault identification (FID) is fundamentally ...
Chun-Wei Kong +2 more
openaire +2 more sources
Development and interaction of segmented fault systems
, 1998 Faults in contractional and extensional settings have been studied, both during fieldwork and from interpretation of 2D and 3D seismic sections. Detailed analysis of the geometries of faults, with displacements of a few mm to 100's m, has provided ...
Kelly, P.G.
core
Active current control in wind power plants during grid faults
, 2010 Modern wind power plants are required and designed to ride through faults in electrical networks, subject to fault clearing. Wind turbine fault current contribution is required from most countries with a high amount of wind power penetration.
Teodorescu, Remus +3 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source