Results 131 to 140 of about 34,009 (308)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Current motion on faults of the San Andreas system in central California inferred from recent GPS and terrestrial survey measurements [PDF]
, 1995 The San Andreas fault system of California comprises dominantly right-lateral strike-slip faults and forms part of the Pacific-North American plate boundary. This fault system has been studied extensively using geological and geophysical methods since it
Williams, Simon D.P.
core
, 2018 Is there an upper limit to normal fault slip rates? The Mai’iu fault, located within the rapidly extending Woodlark Rift, Papua New Guinea, is one of few active continental low-angle normal faults (LANFs) globally.
S. Webber +9 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Active faults in the eatern gulf of Corinth
, 2014 Active Faults in Eastern and Central CorinthThe eastern and central regions of the Corinthian prefecture is traditionally considered as an area affected by active normal faults. Most of these faults are more or less of E-W direction.
Ασημακόπουλος, Μάριος +1 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Deformation Processes Adjacent to Active Faults: Examples from Eastern California
, 2008 Major seismogenic faults occur within bands of inelastic off-fault deformation (OFD), where both distributed displacement and modification of rock properties occur.
Shelef, Eitan
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Avoidance distance and influence range of active faults: A case study of Litang fault
Dizhi lixue xuebaoObjective Active faults can not only trigger strong earthquakes, but also cause engineering breaks, creep deformation, and geological disasters, which seriously threaten the planning, construction, and safe operation of major projects.
YANG Zhen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source