Results 111 to 120 of about 34,009 (308)

Editorial: Active faults and earthquake due to continental deformation

Frontiers in Earth Science, 2022
Chuanyou Li, Wenjun Zheng, Daoyang Yuan, Zhuqi Zhang   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

High-impedance faulty feeder detection for cross-country faults in distribution networks based on zero-sequence active power regulation

International Journal of Electrical Power & Energy Systems
The weak characteristics of high-impedance faults and the complex attributes of cross-country faults make faulty feeder detection of cross-country high-impedance faults difficult in medium-voltage networks. This paper deduces the zero-sequence equivalent
Yuting Lan, Kun Yu, Xiangjun Zeng, Rong Cai, Qingbo Deng, Chenyu Wu, Shigeng He, Shijie Xu, Youcheng Jia   +8 more
doaj   +1 more source

A SEISMOTECTONIC MAP OF EASTERN SIBERIA

Геодинамика и тектонофизика, 2015
The paper reviews goals and objectives, stages and the content of seismotectonic studies conducted in Eastern Siberia. Such studies are based on a comprehensive analysis of geological and geophysical data and provide for establishing whether the local ...
Valery S. Imaev, Lyudmila P. Imaeva, Oleg P. Smekalin, Boris M. Koz’min, Nikolai N. Grib, Anatoly V. Chipizubov   +5 more
doaj   +1 more source

Earthquakes and active faults in Wyoming

, 1997
Earthquakes and active faults in ...
J.C. Case (10069831)
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

ABOUT THE WAVE MECHANISM OF ACTIVATION OF FAULTS IN SEISMIC ZONES OF THE LITHOSPHERE IN MONGOLIA

Геодинамика и тектонофизика, 2015
The study is focused on earthquake migrations along active faults in seismic zones of Mongolia. The earthquake migrations are interpreted as a result of the influence of deformational waves.
M. G. Mel’nikov
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analysis of fault networks and conjugate systems

, 2013
Faults networks exist over a range of scales and are important for understanding the brittle deformation and fluid transport processes within the Earth’s crust.
Nixon, Casey William
core