Results 71 to 80 of about 223,238 (261)

Current-limiting strategy based on PR controller and active power filter for droop controlled microgrid

open access: yesThe Journal of Engineering, 2019
In order to protect the power electronic equipment and make the output current amplitude of distributed generation (DG) maintain a stable value for different short-circuit faults, this paper proposed a current-limiting strategy based on proportional ...
Jie Gao, Xiaowei Wang, Fengfeng Yang
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

A Novel Discrete Resonant Control Method for Cascaded H-Bridge Rail Balancers

open access: yesPower Electronics and Drives
This paper presents the concept of an advanced rail balancer (ARB) for next-generation traction substations (TSSs), along with its control algorithm based on a novel advanced resonant controller.
Straka Milos   +5 more
doaj   +1 more source

Shunt active DC filter based on intelligence controller for HVDC link

open access: yesHigh Voltage, 2017
A shunt active DC filter (ADF) with current injection suppresses current harmonics from high-voltage DC (HVDC) transmission systems. This paper proposes an ADF based on artificial neural networks (ANNs). The ANNs are very generic, accurate and convenient
Seyedreza Aali
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

A Single-Ended and Fully-Differential Universal Current-Mode Frequency Filter with MO-CF and DACA Elements

open access: yesAdvances in Electrical and Computer Engineering, 2016
The paper presents proposal of the 2nd-order universal frequency filter. The presented filter operates in the current-mode and it is designed in the single-ended and fully-differential form. Signal-flow graphs (SFG) method has been used in the proposal.
LANGHAMMER, L.   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

LCL Interface Filter Design for Shunt Active Power Filters

open access: yesAdvances in Electrical and Computer Engineering, 2010
This paper is focused on finding the parameters of a second order interface filter connected between the power system and the shunt active filter based on switching frequency of the active filter.
DOBRICEANU, M.   +3 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

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