Results 91 to 100 of about 2,946,753 (305)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Control of unsteady separated flow associated with the dynamic stall of airfoils [PDF]
The two principal objectives of this research were to achieve an improved understanding of the mechanisms involved in the onset and development of dynamic stall under compressible flow conditions, and to investigate the feasibility of employing adaptive ...
Wilder, Michael C.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Numerical Analysis of a Bidirectional Synthetic Jet for Active Flow Control [PDF]
, 2017 Nishino, Takafumi, Savill, Mark A.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Gym-preCICE: Reinforcement learning environments for active flow control [PDF]
, 2023 Mosayeb Shams, Ahmed H. Elsheikh
openalex +1 more source
Stability and control of compressible flows over a surface with concave-conves curvature [PDF]
The active control of spatially unstable disturbances in a laminar, two-dimensional, compressible boundary layer over a curved surface is numerically simulated. The control is effected by localized time-periodic surface heating.
Bayliss, A. +3 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Thyristor Switched Smart Transformer for Active Power Flow Control in Multi Micro grid System
, 2017 V. Sankar, G. Haritha, Manjula G. Nair
openalex +1 more source