Results 81 to 90 of about 1,024,804 (310)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Effects of Input Voltage and Freestream Velocity on Active Flow Control of Passage Vortex in a Linear Turbine Cascade Using Dielectric Barrier Discharge Plasma Actuator

Energies, 2020
Passage vortex exists as one of the typical secondary flows in turbomachines and generates a significant total pressure loss and degrades the aerodynamic performance. Herein, a dielectric barrier discharge (DBD) plasma actuator was utilized for an active
Takayuki Matsunuma, Takehiko Segawa
doaj   +1 more source

Active Flow Separation Control on a High-Lift Wing-Body Configuration - Part 1: Baseline Flow and Constant Blowing

, 2011
This paper describes the influence of grid resolution and turbulence modeling for a 3D transport aircraft in high lift configuration with massive flap separation.
Breitenstein, Wiebke, Rudnik, Ralf, Kühn, Timo, Ciobaca, Vlad, Gölling, Burkhard   +4 more
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An Experimental Investigation by Particle Image Velocimetry of the Active Flow Control of the Stall Inception of an Axial Compressor

International Journal of Turbomachinery, Propulsion and Power
This paper presents results from active flow control experiments carried out on a single stage axial compressor. The flow under various forced conditions has been investigated using 2D 2C particle image velocimetry (PIV) on three radial planes along the ...
Olha Alekseik, Pierric Joseph, Olivier Roussette, Antoine Dazin   +3 more
doaj   +1 more source

Control flow in active inference systems

, 2023
Living systems face both environmental complexity and limited access to free-energy resources. Survival under these conditions requires a control system that can activate, or deploy, available perception and action resources in a context specific way. We show here that when systems are described as executing active inference driven by the free-energy ...
Chris Fields, Filippo Fabrocini, Karl Friston, James F. Glazebrook, Hananel Hazan, Michael Levin, Antonino Marcianò   +6 more
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Active Flow Separation Control on a High-Lift Wing-Body Configuration. Part 2: The Pulsed Blowing Application.

, 2011
This contribution discusses the implementation of active flow separation control for a 3D high-lift wing-body configuration under atmospheric low-speed wind tunnel conditions.
Rudnik, Ralf, Bauer, Matthias, Kühn, Timo, Ciobaca, vlad, Gölling, Burkhard   +4 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source