Results 1 to 10 of about 221,932 (171)

A juvenile mouse model of anti-N-methyl-D-aspartate receptor encephalitis by active immunization [PDF]

Frontiers in Molecular Neuroscience, 2023
IntroductionAnti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a common autoimmune encephalitis, and it is associated with psychosis, dyskinesia, and seizures.
Shuyu He, Shuyu He, Shuyu He, Chongyang Sun, Chongyang Sun, Qian Zhu, Qian Zhu, Lin Li, Jianyu Huang, Ge Wu, Ge Wu, Yi Cao, Jianxiang Liao, Yi Lu, Qiru Su, Sufang Lin, Xiaopeng Ma, Cheng Zhong   +17 more
doaj   +2 more sources

Optimizing animal models of autoimmune encephalitis using active immunization [PDF]

Frontiers in Immunology, 2023
Background and objectivesEncephalitis is a devastating neurologic disorder with high morbidity and mortality. Autoimmune causes are roughly as common as infectious ones.
Jenny Linnoila, Jenny Linnoila, Negin Jalali Motlagh, Negin Jalali Motlagh, Grace Jachimiec, Chih-Chung Jerry Lin, Enrico Küllenberg, Enrico Küllenberg, Gregory Wojtkiewicz, Rudolph Tanzi, John W. Chen, John W. Chen   +11 more
doaj   +2 more sources

Protective Effects against the Development of Alzheimer’s Disease in an Animal Model through Active Immunization with Methionine-Sulfoxide Rich Protein Antigen [PDF]

Antioxidants, 2022
The brain during Alzheimer’s disease (AD) is under severe oxidative attack by reactive oxygen species that may lead to methionine oxidation. Oxidation of the sole methionine (Met35) of beta-amyloid (Aβ), and possibly methionine residues of other ...
Adam S. Smith, Kyle R. Gossman, Benjamin Dykstra, Fei Philip Gao, Jackob Moskovitz   +4 more
doaj   +2 more sources

A New Strategy Toward B Cell-Based Cancer Vaccines by Active Immunization With Mimotopes of Immune Checkpoint Inhibitors [PDF]

Frontiers in Immunology, 2020
Therapeutic monoclonal antibodies (mAbs), targeting tumor antigens, or immune checkpoints, have demonstrated a remarkable anti-tumor effect against various malignancies.
Joshua Tobias, Claire Battin, Annika De Sousa Linhares, Michael Lebens, Karin Baier, Katharina Ambroz, Mirjana Drinić, Sandra Högler, Aleksandra Inic-Kanada, Erika Garner-Spitzer, Matthias Preusser, Lukas Kenner, Lukas Kenner, Michael Kundi, Christoph C. Zielinski, Peter Steinberger, Ursula Wiedermann   +16 more
doaj   +2 more sources

Progress in the preparation of an active immunization model of anti-N-methyl-D-aspartate receptor encephalitis in animals [PDF]

Frontiers in Immunology
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common form of autoimmune encephalitis, and its primary immunologic mechanism is that NMDA antibodies bind to the NMDA receptor, causing NMDAR to internalize and weaken to trigger ...
Kuikui Zeng, Yuting Liu, Sai Yang, Lingjuan Liu   +3 more
doaj   +2 more sources

Live Birth Rates after Active Immunization with Partner Lymphocytes [PDF]

Biomedicines, 2021
Although many potential causes have been established for recurrent implantation failure (RIF) and recurrent miscarriage (RM), about 50% of these remain idiopathic. Scientific research is focused on immunological risk factors. In the present study, we aim
Veronika Günther, Ibrahim Alkatout, Lisa Meyerholz, Nicolai Maass, Siegfried Görg, Sören von Otte, Malte Ziemann   +6 more
doaj   +2 more sources

Effect of active immunization with recombinant-derived goose INH-α, AMH, and PRL fusion protein on broodiness onset and egg production in geese (Anser cygnoides) [PDF]

Poultry Science, 2021
: This study was conducted to investigate the potential effects of active immunization against recombinant-derived goose inhibin-α (INH-α), anti-Müllerian hormone (AMH), and prolactin (PRL) fusion protein on broodiness onset and egg production in geese ...
Y. Zhang, Z.Y. Chen, C. An, K.Q. Weng, Z.F. Cao, Q. Xu, G.H. Chen   +6 more
doaj   +2 more sources

Anti-NMDAR encephalitis induced in mice by active immunization with a peptide from the amino-terminal domain of the GluN1 subunit [PDF]

Journal of Neuroinflammation, 2021
Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently discovered autoimmune syndrome associated with psychosis, dyskinesia, and seizures.
Yuewen Ding, Zheye Zhou, Jinyu Chen, Yu Peng, Haitao Wang, Wei Qiu, Wei Xie, Jun Zhang, Honghao Wang   +8 more
doaj   +2 more sources

Wastewater-based surveillance identifies start to the pediatric respiratory syncytial virus season in two cities in Ontario, Canada

Frontiers in Public Health, 2023
IntroductionDetection of community respiratory syncytial virus (RSV) infections informs the timing of immunoprophylaxis programs and hospital preparedness for surging pediatric volumes. In many jurisdictions, this relies upon RSV clinical test positivity
Elisabeth Mercier, Lakshmi Pisharody, Fiona Guy, Shen Wan, Nada Hegazy, Patrick M. D’Aoust, Md Pervez Kabir, Tram Bich Nguyen, Walaa Eid, Bart Harvey, Erin Rodenburg, Candy Rutherford, Alex E. Mackenzie, Alex E. Mackenzie, Jacqueline Willmore, Charles Hui, Charles Hui, Bosco Paes, Robert Delatolla, Nisha Thampi, Nisha Thampi   +20 more
doaj   +1 more source

Immunization With Recombinant Haemonchus contortus Y75B8A.8 Partially Protects Local Crossbred Female Goats From Haemonchus contortus Infection

Frontiers in Veterinary Science, 2022
Haemonchus contortus Y75B8A.8 (Hc8) derived from H. contortus excretory–secretory (ES) products was identified as a functional inhibitor of goat interleukin 2 (IL-2). It may act as a vaccine candidate for the development of therapeutic strategies against
Xiaowei Tian, Xiaowei Tian, Mingmin Lu, Yongqian Bu, Yang Zhang, Kalibixiati Aimulajiang, Meng Liang, Charles Li, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li, Xiangrui Li   +12 more
doaj   +1 more source