Results 11 to 20 of about 3,253,605 (155)

A New Strategy Toward B Cell-Based Cancer Vaccines by Active Immunization With Mimotopes of Immune Checkpoint Inhibitors

Frontiers in Immunology, 2020
Therapeutic monoclonal antibodies (mAbs), targeting tumor antigens, or immune checkpoints, have demonstrated a remarkable anti-tumor effect against various malignancies.
Joshua Tobias, Claire Battin, Annika De Sousa Linhares, Michael Lebens, Karin Baier, Katharina Ambroz, Mirjana Drinić, Sandra Högler, Aleksandra Inic-Kanada, Erika Garner-Spitzer, Matthias Preusser, Lukas Kenner, Lukas Kenner, Michael Kundi, Christoph C. Zielinski, Peter Steinberger, Ursula Wiedermann   +16 more
doaj   +1 more source

Immunotherapies for Neurodegenerative Diseases

Frontiers in Neurology, 2021
The current treatments for neurodegenerative diseases are mostly symptomatic without affecting the underlying cause of disease. Emerging evidence supports a potential role for immunotherapy in the management of disease progression. Numerous reports raise
Ibrahim Mortada, Raymond Farah, Sanaa Nabha, David M. Ojcius, Youssef Fares, Wassim Y. Almawi, Najwane Said Sadier, Najwane Said Sadier   +7 more
doaj   +1 more source

Atheroregressive Potential of the Treatment with a Chimeric Monoclonal Antibody against Sulfated Glycosaminoglycans on Pre-existing Lesions in Apolipoprotein E-Deficient Mice

Frontiers in Pharmacology, 2017
The retention of lipoprotein particles in the intima, in particular to glycosaminoglycan side chains of proteoglycans, is a critical step in atherosclerosis initiation.
Victor Brito, Victor Brito, Katia Mellal, Karina F. Zoccal, Karina F. Zoccal, Yosdel Soto, Yosdel Soto, Liliane Ménard, Roger Sarduy, Lucia H. Faccioli, Huy Ong, Ana M. Vázquez, Sylvie Marleau   +12 more
doaj   +1 more source

Protective Effects against the Development of Alzheimer’s Disease in an Animal Model through Active Immunization with Methionine-Sulfoxide Rich Protein Antigen

Antioxidants, 2022
The brain during Alzheimer’s disease (AD) is under severe oxidative attack by reactive oxygen species that may lead to methionine oxidation. Oxidation of the sole methionine (Met35) of beta-amyloid (Aβ), and possibly methionine residues of other ...
Adam S. Smith, Kyle R. Gossman, Benjamin Dykstra, Fei Philip Gao, Jackob Moskovitz   +4 more
doaj   +1 more source

Reduced Susceptibility to Penicillin among Pneumococci Causing Invasive Infection in Children - Canada, 1991-1998

Canadian Journal of Infectious Diseases, 2001
OBJECTIVE: To determine, over time, the rate and serotypes of pneumococci with reduced penicillin susceptibility obtained from children with invasive infection.
David Scheifele, Scott Halperin, Louise Pelletier, James Talbot, Marguerite Lovgren, Wendy Vaudry, Taj Jadavji, Barbara Law, Noni MacDonald, Ron Gold, Elaine Wang, Elaine Mills, Marc Lebel, Pierre Déry, Rob Morris   +14 more
doaj   +1 more source

Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice

Journal of Lipid Research, 2012
Successful development of drugs against novel targets crucially depends on reliable identification of the activity of the target gene product in vivo and a clear demonstration of its specific functional role for disease development.
Elena Fattori, Manuela Cappelletti, Paola Lo Surdo, Alessandra Calzetta, Claus Bendtsen, Yan G. Ni, Shilpa Pandit, Ayesha Sitlani, Giuseppe Mesiti, Andrea Carfí, Paolo Monaci   +10 more
doaj   +1 more source

In vivo Mechanisms of Antibody-Mediated Neurological Disorders: Animal Models and Potential Implications

Frontiers in Neurology, 2020
Over the last two decades, the discovery of antibodies directed against neuronal surface antigens (NSA-Abs) in patients with different forms of encephalitis has provided a basis for immunotherapies in previously undefined disorders. Nevertheless, despite
Maria Pia Giannoccaro, Maria Pia Giannoccaro, Sukhvir K. Wright, Sukhvir K. Wright, Angela Vincent   +4 more
doaj   +1 more source

Imunização ativa e passiva no prematuro extremo Active and passive immunization in the extremely preterm infant

Jornal de Pediatria, 2005
OBJETIVO: Revisão sobre a indicação, contra-indicação, época ideal, eficácia imunogênica e reatogenicidade (eventos adversos) das imunizações passiva e ativa nos RN pré-termo extremos.
Eduardo C. Tavares, José Geraldo Ribeiro, Lorenza A. Oliveira   +2 more
doaj   +1 more source

Poliomyelitis Outbreak,Pointe-Noire, Republic of the Congo, September 2010–February 2011

Emerging Infectious Diseases, 2011
On November 4, 2010, the Republic of the Congo declared a poliomyelitis outbreak. A cross-sectional survey in Pointe-Noire showed poor sanitary conditions and low vaccination coverage (55.5%), particularly among young adults.
Arnaud Le Menach, Augusto E. Llosa, Isabelle Mouniaman-Nara, Felix Kouassi, Joseph Ngala, Naomi Boxall, Klaudia Porten, Rebecca F. Grais   +7 more
doaj   +1 more source

Active and Passive Immunization with Myelin Basic Protein as a Method for Early Treatment of Traumatic Spinal Cord Injury; a Meta-Analysis

Archives of Academic Emergency Medicine, 2021
Introduction: Traumatic spinal cord injury (SCI), as a dangerous central nervous system damage, continues to threaten communities by imposing various disabilities and costs.
Mahmoud Yousefifard, Arian Madani Neishaboori, Seyedeh Niloufar Rafiei Alavi, Amirmohammad Toloui, Mohammed I M Gubari, Amirali Zareie Shab Khaneh, Maryam Karimi Ghahfarokhi, Mostafa Hosseini   +7 more
doaj   +1 more source