Results 101 to 110 of about 118,708 (290)

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Extraction of Leukemia Associated antigen (LAA) and Active Specific Immunization with LAA in Acute Leukemia [PDF]

, 1980
1980-03Leukemia associated antigen (LAA) was prepared from leukemia cells, using hypotonic lysis and low frequency sonications, followed by diethylaminoethyl (DEAE) cellulose column chromatography.
EZAKI, KOHJI
core   +1 more source

Therapeutic nanoliposome vaccine targeting multiple Aβ and tau epitopes reduces AD-like brain pathologies and rescues cognitive deficits in 3xTg-AD mice

Brain, Behavior, & Immunity - Health
Amyloid beta (Aβ) plaques and hyperphosphorylated tau neurofibrillary tangles (NFTs) are the histopathological hallmarks of Alzheimer's disease (AD) and targets for AD therapeutics. Since Aβ and tau pathologies both drive AD pathogenesis and progression,
Chun-Ling Dai, Yiting Song, Yonghua Chen, Yunn Chyn Tung, Wei-Chiao Huang, Cheng-Xin Gong, Jonathan F. Lovell   +6 more
doaj   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Active and passive immunization for atherosclerosis

, 2007
This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies.
Chyu, Kuang-Yuh, Nilsson, Jan, Shah, Prediman K.   +2 more
core  

Immune activation and immune aging in HIV infection

Current Opinion in HIV and AIDS, 2016
The development of serious non-AIDS-related pathologies typically associated with aging, and the premature immune aging that characterizes HIV-1-infected patients, even with suppressive antiretroviral therapy, have raised increasing concerns in recent years.
Appay, V, Kelleher, AD
openaire   +3 more sources

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Polyantigenic Interferon-γ Responses are Associated with Protection from TB Among HIV-Infected Adults with Childhood BCG Immunization. [PDF]

, 2011
Surrogate immunologic markers for natural and vaccine-mediated protection against tuberculosis (TB) have not been identified. HIV-infected adults with childhood BCG immunization entering the placebo arm of the DarDar TB vaccine trial in Dar es Salaam ...
Horsburgh, C Robert, Jenni M. Vuola, Mtei, L., Bakari, M, Pallangyo, K., Mitchell, B.K., Arbeit, R.D., C. Robert Horsburgh, Bakari, Muhammad, Matee, Mecky, C. Fordham von Reyn, Lillian Mtei, Sheth, S., Robert D Arbeit, Arbeit, Robert D, Mtei, Lillian, Mitchell, Brian K, C. Robert Horsburgh5, Muhammad Bakari, MacKenzie, T, Lahey, Timothy, Robert D. Arbeit, Todd MacKenzie, C. Fordham von Reyn1, Matee, M., Sheth, Siddharth, Brian K. Mitchell, Horsburgh, C.R., Vuola, Jenni M, Siddharth Sheth, Mecky Matee, Timothy Lahey, Pallangyo, Kisali, Jenni M Vuola, Kisali Pallangyo, C Fordham von Reyn, von Reyn, C.F., MacKenzie, Todd, Lahey, T., Vuola, J.M., von Reyn, C Fordham, C Robert Horsburgh, Brian K Mitchell   +42 more
core   +1 more source

A brief history of antibody-based therapy

Neurobiology of Disease, 2019
Active and passive immunization have been used to treat human disease for hundreds of years and improvements in technology and knowledge is only increasing the number of therapeutic applications.
M. Alpaugh, F. Cicchetti
doaj   +1 more source

Measuring polio immunity to plan immunization activities

Vaccine, 2016
The Global Polio Eradication Initiative is closer than ever to achieving a polio-free world. Immunization activities must still be carried out in non-endemic countries to maintain population immunity at levels which will stop poliovirus from spreading if it is re-introduced from still-infected areas.
Voorman, Arend, Lyons, Hil M.
openaire   +2 more sources