Results 141 to 150 of about 118,708 (290)

Circular mRNA against CleanCap linear mRNA vectors: comprehensive comparison, expression, active and passive immunization

Frontiers in Immunology
IntroductionThe mRNA platform has revolutionised vaccine technology by offering a universal, rapid, and easily scalable production process. Two main types of mRNA vectors exist—linear (cap‑dependent) and circular (cap‑independent)—each with distinct ...
Vladimir M. Vakhtinskii, Irina L. Tutykhina, Alina S. Dzharullaeva, Daria M. Grousova, Ilya D. Zorkov, Anna A. Ilyukhina, Dmitrii A. Reshetnikov, Valentin V. Azizyan, Artem A. Derkaev, Evgeniia N. Bykonia, Evgeny V. Usachev, Denis A. Kleymenov, Vladimir A. Gushchin, Vladimir A. Gushchin, Vladimir A. Gushchin, Inna V. Shuliakova, Dmitry V. Shcheblyakov, Maxim M. Shmarov, Denis Yu. Logunov, Alexander L. Gintsburg, Alexander L. Gintsburg   +20 more
doaj   +1 more source

Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models. [PDF]

Clin Sci (Lond), 2023
Sun H, Song J, Li K, Li Y, Shang L, Zhou Q, Lu Y, Zong Y, He X, Kari M, Yang H, Zhou X, Zhang L, Tang B.   +13 more
europepmc   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Active immunization combined with cisplatin confers enhanced therapeutic protection and prevents relapses of HPV-induced tumors at different anatomical sites. [PDF]

Int J Biol Sci, 2022
Porchia BFMM, Aps LRMM, Moreno ACR, da Silva JR, Silva MO, Sales NS, Alves RPDS, Rocha CRR, Silva MM, Rodrigues KB, Barros TB, Pagni RL, Souza PDC, Diniz MO, Ferreira LCS.   +14 more
europepmc   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Immunization of adults

, 2018
The nature and function of passive and active immunization, the role of humoral and cellular immunity in vaccination, the types of vaccines currently available and the pros and cons of their use is given in the lecture.
Bondarenko, Andriy
core  

A real-world based study for immunogenicity and safety for three immunization schedules of polio vaccine

Scientific Reports
To evaluate the immunogencity and safety for three immunization schedules of inactivated poliovirus vaccine (IPV) and bivalent oral poliovirus vaccine (bOPV) for providing a basis for further optimization of the polio sequential immunization schedule. To
Li Sun, Shi-fan Wang, Yi-qing Zhu, Ya-fei Wang, Jun-mian Zhang, Jing-hui Wang, Yan-li Cong, Jing Li, Xiao-qin Liu, Sha-sha Han, Yu Guo, Qi Li   +11 more
doaj   +1 more source

Anti-NMDAR encephalitis induced in mice by active immunization with a peptide from the amino-terminal domain of the GluN1 subunit. [PDF]

J Neuroinflammation, 2021
Ding Y, Zhou Z, Chen J, Peng Y, Wang H, Qiu W, Xie W, Zhang J, Wang H.   +8 more
europepmc   +1 more source

Risk of venous thromboembolism after SARS‐CoV‐2 vaccination—Evidence from genome‐wide association study and population‐based observational study

British Journal of Clinical Pharmacology, EarlyView.
Aim We aimed to investigate whether genetic variation is associated with venous thromboembolism after immunization with SARS‐CoV‐2 vaccines. Methods We conducted a genome‐wide association study (GWAS) on cases of venous thromboembolism within 42 days after SARS‐CoV‐2 vaccination, recruited from reports of adverse drug reactions sent to the Swedish ...
Sofia Attelind, Niclas Eriksson, Marco Cavalli, Yiyi Xu, Fredrik Nyberg, Anders Sundström, Mia Wadelius, Pär Hallberg   +7 more
wiley   +1 more source