Results 181 to 190 of about 118,708 (290)

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

open access: yesInterdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu   +11 more
wiley   +1 more source

Nanoparticles as a carrier for protein and plasmid DNA vaccines in microneedle-mediated transcutaneous immunization

open access: yes, 2014
textSkin is the largest immune organ and an ideal site to administer vaccines. However, by nature, skin is not permeable to antigens, which are macromolecules. The major hurdle in skin permeation is the outermost stratum corneum layer.
Kumar, Amit, active 21st century
core   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

open access: yesInterdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang   +10 more
wiley   +1 more source

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors. [PDF]

open access: yesSci Transl Med, 2019
Jones BE   +6 more
europepmc   +1 more source

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

open access: yesInterdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen   +6 more
wiley   +1 more source

An evaluation of contingent immunization

open access: yes
This paper tests the effectiveness of contingent immunization, a stop loss strategy that allows portfolio managers to take advantage of their ability to forecast interest rate movements as long as their forecasts are successful, but switches to a pure ...
Skinner, Frank S.   +3 more
core  

Success Framework for Adult Immunization Partner Networks Case Study: Connecticut Diversifying Partners within an Immunization Coalition [PDF]

open access: yes
Connecticut is a jurisdiction with a decentralized governance model that has worked with a medium-sized partner network: 30-50 active members of the Connecticut Immunization Coalition (CIC) (such as adult providers, pharmacies, non-profit organizations ...

core  

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

open access: yesInterdisciplinary Medicine, EarlyView.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma   +6 more
wiley   +1 more source

Corrigendum: Wastewater-based surveillance identifies start to the pediatric respiratory syncytial virus season in two cities in Ontario, Canada

open access: yesFrontiers in Public Health
Elisabeth Mercier   +20 more
doaj   +1 more source

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