Results 141 to 150 of about 129,145 (314)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

From fruit to function: Squalene synthase driven triterpenoids biosynthesis in <i>Gardenia jasminoides</i> for food-active ingredient discovery. [PDF]

Food Chem X
Wei W, Mao Y, Chen D, Guo L, Pan Y.
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Metabolomics and Transcriptomics Analyses Explore the Genes Related to the Biosynthesis of Antioxidant Active Ingredient Isoquercetin. [PDF]

Foods
Cui L, Yang J, Yuan R, Wang S, Ma Z, Wang D, Niu Y.   +6 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

"Same active ingredient": what FDA warning letters allege about compounded GLP-1 sellers

Peter Kalafatis
openalex   +1 more source

Can dual active ingredient Interceptor® G2 insecticide-treated net (ITN) replace indoor residual spraying (IRS) efficiently? A case study in Sakassou, Côte d'Ivoire. [PDF]

Parasit Vectors
Chabi J, Shirima GS, Masanja B, Coleman S, N'Guessan Gbalegba CG, Kouassi BL, N'Guessan Broudje BR, Ako Edi CV, Yokoly FN, Adimi WO, Kouame RA, Anian V, Kyerematen R, Egyir-Yawson A, Kiware S, Dadzie SK.   +15 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Synthesis and Structural Elucidation of Nitrosamine Impurities in Active Pharmaceutical Ingredients

Pooja S Dalvi Sharad S Sankhe
openalex   +2 more sources

Analysis of the use of trade names versus active ingredient names using the example of acetylsalicylic acid and Aspirin® in the Frankfurter Allgemeine Zeitung. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Krug E, Seifert R.
europepmc   +1 more source