Results 161 to 170 of about 129,145 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

THE EFFECTS OF ACTIVE INGREDIENTS IN TOOTHPASTES ON DENTAL ENAMEL AND PERIODONTAL TISSUES: A NARRATIVE REVIEW

Xasanova Iroda Ikromjon qizi, Sadikova Iroda Yangiboyevna   +1 more
openalex   +1 more source

Predictive sustainability in agriculture: Machine learning analysis of active ingredient restrictions and bans. [PDF]

PLOS Glob Public Health
Brunini RG.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Olive Oil as a Potential Source of Anticancer Phytochemicals: In Vitro and Preclinical Evaluation of Active Ingredients and Their Synergism with Conventional Treatments

Wamidh H. Talib, Intisar Hadi Al-Yasari, Jomana Alqannas, Shahd Mismar, Doaa Omar Anbarserry, Wafa` A. Ahmad, Douglas Sie Nguong Law, Ahmad Riyad Alsayed, Bence László Raposa   +8 more
openalex   +1 more source

Recent Progress in Nano-TCM Active Ingredient Co-Delivery Systems for Inflammation-Mediated Diseases. [PDF]

Int J Nanomedicine
Sun C, Chen J, Bai S, Liao W, Chen J, Guo W, Zeng L, Yu L.   +7 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Determination of 226Ra in 225Ac Active Pharmaceutical Ingredients by ICP-QQQ-MS

Jakob E. Baumeister, Benjamin W. Puffer, Miguel Toro-González, Joshua B. McCormick, Cory A. Hawkins, Daniel J. de Vries   +5 more
openalex   +1 more source

Storage stability of hospital-prepared mianserin suppositories: evaluation of residual active ingredient content and bacteriological contamination under different storage conditions. [PDF]

J Pharm Health Care Sci
Tanaka R, Ichikawa T, Sato J.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source