Results 181 to 190 of about 129,145 (314)

'Active ingredient' for a healthy life

Journal of Osteopathic Medicine, 1996
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Exclusive patent, know-how, process and trade secret license and sublicense to develop, make, have made, use, import, offer, market, commercialize, distribute, sell, dispose of, and sublicense the bucindolol compound and final products containing the compound as therapeutically active ingredient for sale by prescription, over-the-counter or other method for all therapeutic and diagnostic human and animal health uses and indications, which may include congestive heart failure.

RoyaltyStat
openalex   +1 more source

Enhancing active ingredient biosynthesis in Chinese herbal medicine: biotechnological strategies and molecular mechanisms. [PDF]

PeerJ
Guo Z, Yang N, Xu D.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Exclusive patent, know-how and technology license and sublicense, including improvements, to develop, commercialize, use, manufacture, have made, distribute, sell and sublicense transdermal delivery systems containing semaglutide as the sole active pharmaceutical ingredient.

RoyaltyStat
openalex   +1 more source

Maimendong decoction and its active ingredient, ophiopogonin D, alleviate bleomycin-induced pulmonary fibrosis by regulating the behavior of lung fibroblasts. [PDF]

Chin Med
Yang M, Zhang X, Bao S, Yang S, Zhang Y, Liu Y, Li C, Zou J, Li J, Yan S.   +9 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Exclusive patent, know-how, process, technology, software and trade secret license to develop, package, label, commercialize, market, promote, import, distribute, offer, sell, use and sublicense products containing the antibody known as navenibart as an active pharmaceutical ingredient, to prevent hereditary angioedema (HAE) attacks in humans, which may be injected.

RoyaltyStat
openalex   +1 more source

Undeclared Pharmacologically Active Ingredients in Over-the-Counter Skin Products [PDF]

Zaur Abilov, Michael J. James, Martina Lee Porter, Yury V. Popov   +3 more
openalex   +1 more source