Results 201 to 210 of about 129,145 (314)

What are the active ingredients in the intervention for early communication skills in young children (0-3) with Cerebral Palsy? A scoping review.

Charlotte Wigham, Roslyn Ward, Karen Wylie   +2 more
openalex   +1 more source

Phytochemical Investigation of an Ostrya carpinifolia L. Extract: An Effective Anti-Pollution Cosmetic Active Ingredient. [PDF]

Chem Biodivers
Trinel M, Dubois C, Burger P, Plainfossé H, Azoulay S, Verger-Dubois G, Fernandez X.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Camellia Sinensis Extracts Embedded in Semipermeable Nanocapsules as Active Ingredient for Dental Adhesives: Biomaterial Synthesis and Effect on the Bond to Human Dentin. [PDF]

Int J Nanomedicine
Richter-Mendau P, Moldovan M, Cernescu A, Sarosi C, Ilie N.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Nitrosamine Impurities in Active Pharmaceutical Ingredients: Formation Mechanisms, Analytical Profiling, Toxicological Risk Assessment, and Regulatory Control Strategies

Avadhoot Partole, Sahil Shirose, Harshali Shelar, Aditya Jamghare, Suyog Vishe, Monika Vinchu   +5 more
openalex   +1 more source

Analysis of the Aerial Parts of <i>Millettia speciosa</i> Champ. and Mechanistic Study of Its Active Ingredient Formononetin in Improving Metabolic Syndrome. [PDF]

Food Sci Nutr
Niu W, Jian R, Zeng L, Huang Z, Cai J.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Microgravity Crystallization of Active Pharmaceutical Ingredients (APIs): Impact on Crystalline Forms

Kamryn Williams, Jessica Paulson, Miriam Garringer, Joanna Rajkumar, Chloe Brecht, Carson Powers, Lillian Miller, Stephen Tuma, Dom Hebrault, Anne M. Wilson   +9 more
openalex   +1 more source

Caffeine as an Active Ingredient in Cosmetic Preparations Against Hair Loss: A Systematic Review of Available Clinical Evidence. [PDF]

Healthcare (Basel)
Szendzielorz E, Spiewak R.
europepmc   +1 more source