Results 221 to 230 of about 129,145 (314)

Antidepressant effects of ershiwei roudoukou pills and its active ingredient Macelignan: Multiple mechanisms involving oxidative stress, neuroinflammation and synaptic plasticity. [PDF]

Transl Psychiatry
Wang YL, Chen L, Zhong XL, Liu QS, Li WQ, Cheng Y, Du Y.   +6 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Calculation of Mass Balance Chemical Stressed Active Pharmaceutical Ingredients by Example of Oxidized Nicotinamide Dinucleotide

Stanislav V. Yefimov
openalex   +2 more sources

Impact of prior antihypertensive treatment on COVID-19 outcomes, by active ingredient. [PDF]

Inflammopharmacology
García-Álvarez RM, Zapata-Cachafeiro M, Visos-Varela I, Rodríguez-Fernández A, Pintos-Rodríguez S, Piñeiro-Lamas M, Herdeiro TM, Figueiras A, Salgado-Barreira A, COVID-Drug Group.   +9 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

QUANTITATIVE ANALYSIS AND VALIDATION OF ELEMENTAL IMPURITIES IN TERAZOSIN ACTIVE PHARMACEUTICAL INGREDIENT USING ICP-MS ACCORDING TO ICH Q3D REQUIREMENTS

openalex   +1 more source

Examining the spatial effect ranges of new classes of long-lasting insecticidal nets (LLINs) on malaria infection and vector abundance: An anisotropic semivariance analysis in the context of a phase-III cluster-randomised malaria vector control trial of dual active-ingredient LLINs

Thickstun C, Mosha JF, Lukole E, Matowo NS, Mallya E, Martin J, Manjurano A, Feng C, Kleinschmidt I, Mosha FW, Rowland M, Taljaard M, Protopopoff N, Kulkarni MA.   +13 more
europepmc   +1 more source

Inhibitory effects of Lycii fructus water extracts and its active ingredient, zeaxanthin, on receptor activator of nuclear factor κB ligand-induced osteoclast differentiation. [PDF]

Food Sci Biotechnol
Han SY, Choi H, Jo EH, Kim YK.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Evaluation of a Medical Generative AI Environment for Active Ingredient Dose-Equivalence Checking in the Reconciliation of Patients’ own Medications

裕介 石原, Shusuke Kageyama, Ken-ichi Ajiki, Tomohiro Sonoyama, 克樹 横手, Akiyoshi Kanazawa   +5 more
openalex   +2 more sources