Results 231 to 240 of about 129,145 (314)

Development of the active ingredient composition of hand antiseptics in Germany from 2004 to 2022 with special consideration of ethanol as active agent. [PDF]

GMS Hyg Infect Control
Grashoff P, Mutters NT, Kramer A, Ilschner C, Rausch M, Gebel J.   +5 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Occupational Exposure Limits for Active Pharmaceutical Ingredients: A Comparative Review of ICH Q3C, OSHA, NIOSH, and European Medicines Agency Regulatory Frameworks and their Implications for Worker Health Surveillance

Agilandeswari Devarajan, K. Murali, Sudarshan Bhimappa Daddi, Shivraj Patil, N. Nithya Shree, Bhavana Kavalipurapu, H. M. Megha, Harshita Nehru   +7 more
openalex   +1 more source

Kombucha as a Potential Active Ingredient in Cosmetics-An Ex Vivo Skin Permeation Study. [PDF]

Molecules
Jakubczyk K, Nowak A, Muzykiewicz-Szymańska A, Kucharski Ł, Szymczykowska K, Janda-Milczarek K.   +5 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Comprehensive analysis on the regulatory mechanism of active ingredient accumulation during fermentation process of Massa Medicata Fermentata: microbe and metabolic profiles. [PDF]

Front Microbiol
Li Y, Wang YJ, Guo XP, Zhao HY, Ren HW, Li HY.   +5 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Method Development, Optimization And Validation For Simultaneous Estimation Of Dapagliflozin And Bisoprolol In Active Pharmaceutical Ingredient And Pharmaceutical Dosage Form By RP-HPLC Method

V. Amritha1*, D. Jothieswari2, B. Swarupa3
openalex   +1 more source

Quercitrin, the primary active ingredient of <i>Albizia julibrissin</i> Durazz. flowers, alleviates methamphetamine-induced hepatotoxicity through a mitochondria-mediated apoptosis pathway. [PDF]

Front Pharmacol
Wu D, Xie B, Li J, Xiao Z, Shen J, Wu X, Li M, Sun Q, Shen H, Li X, Dai Y, Zhao Y.   +11 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source