Results 91 to 100 of about 540,685 (254)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A minimal spatial cell lineage model of epithelium: tissue stratification and multi-stability
New Journal of Physics, 2018 A minimal model which includes spatial and cell lineage dynamics for stratified epithelia is presented. The dependence of tissue steady state on cell differentiation models, cell proliferation rate, cell differentiation rate, and other parameters are ...
Wei-Ting Yeh, Hsuan-Yi Chen
doaj +1 more source
Defect order in active nematics on a curved surface
New Journal of Physics, 2020 We investigate the effects of extrinsic curvature on the turbulent behavior of a 2D active nematic confined to the surface of a cylinder. The surface of a cylinder has no intrinsic curvature and only extrinsic curvature.
D J G Pearce
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Hydrodynamics of thermal active matter [PDF]
Physical Review EActive matter concerns many-body systems comprised of living or self-driven agents that collectively exhibit macroscopic phenomena distinct from conventional passive matter. Using Schwinger-Keldysh effective field theory, we develop a novel hydrodynamic framework for thermal active matter that accounts for energy balance, local temperature variations ...
Jay Armas, Akash Jain, Ruben Lier
openaire +4 more sources
New Journal of Physics, 2017 We study the appearance and properties of cluster crystals (solids in which the unit cell is occupied by a cluster of particles) in a two-dimensional system of self-propelled active Brownian particles with repulsive interactions.
Jean-Baptiste Delfau +2 more
doaj +1 more source
An Integrated Cytoskeletal Model of Neurite Outgrowth
Frontiers in Cellular Neuroscience, 2018 Neurite outgrowth underlies the wiring of the nervous system during development and regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics of growth and guidance are not fully understood, and the relative ...
Kyle E. Miller +4 more
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Vortex formation and dynamics of defects in active nematic shells
New Journal of Physics, 2017 We present a hydrodynamic model for a thin spherical shell of active nematic liquid crystal with an arbitrary configuration of defects. The active flows generated by defects in the director lead to the formation of stable vortices, analogous to those ...
Diana Khoromskaia, Gareth P Alexander
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Stochastic Stirling Engine Operating in Contact with Active Baths
Entropy, 2017 A Stirling engine made of a colloidal particle in contact with a nonequilibrium bath is considered and analyzed with the tools of stochastic energetics. We model the bath by non Gaussian persistent noise acting on the colloidal particle. Depending on the
Ruben Zakine +3 more
doaj +1 more source