Results 141 to 150 of about 6,656,778 (331)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Learning Optimal Crowd Evacuation from Scratch Through Self‐Play

open access: yesAdvanced Intelligent Systems
A key goal in evacuation management is to quickly and safely remove panicking crowds from buildings, festivals, or airplanes while preventing crush fatalities.
Mahdi Nasiri   +3 more
doaj   +1 more source

Persistent fluid flows defined by active matter boundaries [PDF]

open access: green, 2020
Zijie Qu   +7 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Noisy active matter

open access: yes
Noise threads every scale of the natural world. Once dismissed as mere background hiss, it is now recognized as both a currency of information and a source of order in systems driven far from equilibrium. From nanometer-scale motor proteins to meter-scale bird flocks, active collectives harness noise to break symmetry, explore decision landscapes, and ...
Chatterjee, Atanu   +2 more
openaire   +2 more sources

Entropy production rate in thermodynamically consistent flocks

open access: yesNew Journal of Physics
We study the entropy production rate (EPR) of aligning self-propelled particles which undergo a flocking transition into a state of polarized collective motion.
Tal Agranov   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Mean first passage time of active Brownian particles in two dimensions

open access: yesNew Journal of Physics
The mean first passage time (MFPT) is a key metric for understanding transport, search, and escape processes in stochastic systems. While well characterized for passive Brownian particles, its behavior in active systems—such as active Brownian particles (
Sarafa A Iyaniwura, Zhiwei Peng
doaj   +1 more source

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