Results 161 to 170 of about 540,685 (254)

Spectral Insights into Active Matter: Exceptional Points and the Mathieu Equation. [PDF]

Entropy (Basel)
Boltz HH, Ihle T.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Inverse Statistics of Active Matter Trajectories to Distinguish Interaction Kernel Anisotropy from Emergent Correlations. [PDF]

Bull Math Biol
Martina-Perez SF.
europepmc   +1 more source

Actin-microtubule dynamic composite forms responsive active matter with memory. [PDF]

Proc Natl Acad Sci U S A, 2022
Kučera O, Gaillard J, Guérin C, Théry M, Blanchoin L.   +4 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Correction: Simulating microswimmers under confinement with dissipative particle (hydro) dynamics

Frontiers in Physics
C. Miguel Barriuso Gutiérrez, José Martín-Roca, José Martín-Roca, Valentino Bianco, Ignacio Pagonabarraga, Ignacio Pagonabarraga, Ignacio Pagonabarraga, Chantal Valeriani, Chantal Valeriani   +8 more
doaj   +1 more source

Approaching active matter from biophysics perspective. [PDF]

Biophys Physicobiol
Hayakawa M, Kawamata I.
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Physical embodiment enables information processing beyond explicit flow sensing in active matter. [PDF]

Sci Adv
Paul D, Milosevic N, Scherf N, Cichos F.
europepmc   +1 more source

Mind the matter: Active matter, soft robotics, and the making of bio-inspired artificial intelligence. [PDF]

Front Neurorobot, 2022
Harrison D, Rorot W, Laukaityte U.
europepmc   +1 more source