Results 71 to 80 of about 321,881 (290)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Metamaterials: Optical Activity without Chirality [PDF]

Physical Review Letters, 2009
We report that the classical phenomenon of optical activity, which is traditionally associated with chirality (helicity) of organic molecules, proteins, and inorganic structures, can be observed in artificial planar media which exhibit neither 3D nor 2D chirality.
Plum, E., Liu, X.X., Fedotov, V.A., Chen, Y., Tsai, D.P., Zheludev, N.I.   +5 more
openaire   +4 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Active 2D materials for on-chip nanophotonics and quantum optics

Nanophotonics, 2017
Two-dimensional materials have emerged as promising candidates to augment existing optical networks for metrology, sensing, and telecommunication, both in the classical and quantum mechanical regimes.
Shiue Ren-Jye, Efetov Dmitri K., Grosso Gabriele, Peng Cheng, Fong Kin Chung, Englund Dirk   +5 more
doaj   +1 more source

Eddington limited starbursts in the central 10pc of AGN, and the Torus in NGC1068 [PDF]

, 2006
We present results from a survey of nearby AGN using the near infrared adaptive optics integral field spectrograph SINFONI. These data enable us to probe the distribution and kinematics of the gas and stars at spatial resolutions as small as 0.085arcsec.
Davies, R., Genzel, R., Sanchez, F. Mueller, Sternberg, A., Tacconi, L.   +4 more
core   +1 more source

Rubidium resonant squeezed light from a diode-pumped optical-parametric oscillator

, 2008
We demonstrate a diode-laser-pumped system for generation of quadrature squeezing and polarization squeezing. Due to their excess phase noise, diode lasers are challenging to use in phase-sensitive quantum optics experiments such as quadrature squeezing.
Caballero, J. M., Mitchell, M. W., Predojević, A., Zhai, Z.   +3 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Association of mid-infrared solar plages with Calcium K line emissions and magnetic structures

, 2007
Solar mid-IR observations in the 8-15 micrometer band continuum with moderate angular resolution (18 arcseconds) reveal the presence of bright structures surrounding sunspots.
A. M. Melo, A. S. Kudaka, Babcock H. W., E. Tandberg-Hanssen, P. Kaufmann, R. Marcon   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Wavefront analysis of a focus-tunable lens with gravity compensation

JPhys Photonics
The application of focus-tunable lenses (FTL) has significantly expanded in the field of photonics in the last decade, establishing these devices as fundamental optoelectronic components in most experimental setups.
E Pérez-Cabré, F Cuéllar, L Clavé, M S Millán   +3 more
doaj   +1 more source