Results 111 to 120 of about 3,484,054 (291)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Trends in the use of natural antioxidants in active food packaging: a review

, 2014
The demand for natural antioxidant active packaging is increasing due to its unquestionable advantages compared with the addition of antioxidants directly to the food.
Buonocore, GG, Sanches-Silva, A., Costa, H.S., Costa, D., Albuquerque, T.G., Castilho, MC, Machado, AV, Ramos, F   +7 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Enhancement in the active food packaging system through metal-based nanomaterials: a review of innovations, challenges, and future directions

Discover Food
Nanotechnology has come up as an advanced domain in the food packaging field that has proved to be an effective solution for increasing shelf life and ensuring food products’ safety.
Nilesh Nirmal, Pranav Vashisht, Sonali Sharma, Lovepreet Singh, Nancy Awasti, Shikhadri Mahanta, Aakash Gill, Kaavya Rathnakumar, Anandu Chandra Khanashyam   +8 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

EFFECT OF MULTILAYER PACKAGING MATERIALS ON THE STABILITY OF THE ACTIVE INGREDIENT TRAMADOL

reservedNel mondo chimico e farmaceutico, la stabilità dei principi attivi è un fattore critico nella formulazione e commercializzazione dei prodotti farmaceutici.
DE SALVO, MATTEO
core  

Study of natural compounds of Rosmarinus Officinalis as additives in food active packaging.

, 2015
The use of natural extracts categorized as flavorings by the European Union (EU) and generally recognized as safe (GRAS) by the US Food and Drug Administration (FDA), represents an interesting approach in the active packaging technology.
C. Cecchini, S. Vittori., G. Caprioli, V. Sirocchi, G. Sagratini, M. M. Coman, M. Ricciutelli   +6 more
core   +1 more source