Results 31 to 40 of about 23,612 (262)

Active pixel sensors: the sensor of choice for future space applications?

SPIE Proceedings, 2007
It is generally known that active pixel sensors (APS) have a number of advantages over CCD detectors if it comes to cost for mass production, power consumption and ease of integration. Nevertheless, most space applications still use CCD detectors because they tend to give better performance and have a successful heritage. To this respect a change may
Leijtens, J. (author), Theuwissen, A. (author), Rao, P.R. (author), Wang, X. (author), Xie, N. (author)   +4 more
openaire   +4 more sources

Towards a new generation of Monolithic Active Pixel Sensors

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2023
A new generation of Monolithic Active Pixel Sensors (MAPS), produced in a 65 nm CMOS imaging process, promises higherdensities of on-chip circuits and, for a given pixel size, more sophisticated in-pixel logic compared to larger feature size processes.MAPS are a cost-effective alternative to hybrid pixel sensors since flip-chip bonding is not required.
Ankur Chauhan, Manuel Del Rio Viera, Doris Eckstein, Finn Feindt, Ingrid-Maria Gregor, Karsten Hansen, Lennart Huth, Larissa Mendes, Budi Mulyanto, Daniil Rastorguev, Christian Reckleben, Sara Ruiz Daza, Paul Schütze, Adriana Simancas, Simon Spannagel, Marcel Stanitzki, Anastasiia Velyka, Gianpiero Vignola, Håkan Wennlöf   +18 more
openaire   +4 more sources

Radiation tolerance of CMOS monolithic active pixel sensors with self-biased pixels [PDF]

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2010
CMOS Monolithic Active Pixel Sensors (MAPS) are proposed as a technology for various vertex detectors in nuclear and particle physics. We discuss the mechanisms of ionizing radiation damage on MAPS hosting the the dead time free, so-called self bias pixel.
Deveaux, M., Amar-Youcef, S., Besson, A., Claus, G., Colledani, C., Dorokhov, M., Dritsa, C., Dulinski, W., Froehlich, I., Goffe, M., Grandjean, D., Heini, S., Himmi, A., Hu, C., Jaaskelainen, K., Muentz, C., Shabetai, A., Stroth, J., Szelezniak, M., Valin, I., Winter, M.   +20 more
openaire   +2 more sources

4H-SiC 64 pixels CMOS image sensors with 3T/4T-APS arrays

Applied Physics Express
For radiation-hardened CMOS image sensors (CIS), 4H-SiC 64 pixel array CIS were developed, and real time imaging with an operation frequency of 30 Hz was demonstrated.
Tatsuya Meguro, Masayuki Tsutsumi, Akinori Takeyama, Takeshi Ohshima, Yasunori Tanaka, Shin-Ichiro Kuroki   +5 more
doaj   +1 more source

Simulation of CMOS APS Operation and Crosstalk in SPICE With Generalized Devices

IEEE Journal of the Electron Devices Society, 2020
We present SPICE simulations of a CMOS APS pixel element consisting of the optical sensor with the sensing circuit. The photodiode is simulated at the physics level by means of the so-called Generalized Devices, without any predefined compact model ...
Chiara Rossi, Jean-Michel Sallese
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A Multi-Resolution Mode CMOS Image Sensor with a Novel Two-Step Single-Slope ADC for Intelligent Surveillance Systems

Sensors, 2017
In this paper, we present a multi-resolution mode CMOS image sensor (CIS) for intelligent surveillance system (ISS) applications. A low column fixed-pattern noise (CFPN) comparator is proposed in 8-bit two-step single-slope analog-to-digital converter ...
Daehyeok Kim, Minkyu Song, Byeongseong Choe, Soo Youn Kim   +3 more
doaj   +1 more source

Improving light collection efficiency using partitioned light guide on pixelated scintillator-based γ-ray imager

Nuclear Engineering and Technology, 2022
When gamma-camera sensor modules, which are key components of radiation imagers, are derived from the coupling between scintillators and photosensors, the light collection efficiency is an important factor in determining the effectiveness with which the ...
Suyeon Hyeon, Mark Hammig, Manhee Jeong
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source