Identification of novel small molecule inhibitors of ETS transcription factors
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla+9 more
wiley +1 more source
Fenton’s reagent-initiated modification of plantain (Musa paradisiaca) peel biomass – mechanisms of chain propagation and dyes removal from simulated wastewaters [PDF]
This report describes the mechanisms of Fenton’s reagent-initiated graft-copolymerization of plantain peel biomass (PPB) and that of the polymer-dyes interactions. Methacrylic acid (MAA) was grafted onto the PPB backbone.
Vincent Oninla+6 more
doaj +1 more source
Evolutionary dynamics in the Bak-Sneppen model on small-world networks [PDF]
We study the dynamics of the Bak-Sneppen model on small-world networks. For each site in the network, we define a ``connectance,'' which measures the distance to all other sites. We find radically different patterns of activity for different sites, depending on their connectance and also on the topology of the network.
arxiv
Monocopper Active Site for Partial Methane Oxidation in Cu-Exchanged 8MR Zeolites
Direct conversion of methane to methanol using oxygen is experiencing renewed interest owing to the availability of new natural gas resources. Copper-exchanged zeolites such as mordenite and ZSM-5 have shown encouraging results, and di- and tri-copper ...
A. Kulkarni+4 more
semanticscholar +1 more source
Novel use of stir bar sorptive extraction (SBSE) as a tool for isolation of oviposition site attractants for gravid Culex quinquefasciatus [PDF]
Mosquitoes such as Culex quinquefasciatus Say (Diptera: Culicidae) are important vectors of organisms that cause disease in humans. Research into the development of effective standardized odour baits for blood-fed females (oviposition attractants), to ...
Birkett, Michael Alexander+8 more
core +2 more sources
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti+3 more
wiley +1 more source
The cytochrome P450 (CYP) family 1A enzymes, CYP1A1 and CYP1A2, are two of the most important enzymes implicated in the metabolism of endogenous and exogenous compounds through oxidation.
Jayalakshmi Sridhar+3 more
doaj +1 more source
Stochastic Models of User-Contributory Web Sites [PDF]
We describe a general stochastic processes-based approach to modeling user-contributory web sites, where users create, rate and share content. These models describe aggregate measures of activity and how they arise from simple models of individual users.
arxiv
Active site engineering for heterogeneous catalysis using emerging nano-structured materials [PDF]
The growing concern about the depletion of oil has spurred worldwide interest in finding alternative feedstocks for important petrochemical commodities and fuels.
Gascón, Jorge
core
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source