Results 181 to 190 of about 4,321,073 (342)

Expected and Unexpected "Guests" at the Active Site of Human Orotidine 5'-Monophosphate Decarboxylase. [PDF]

Biochemistry
Kirck LL, Santagostino E, Brandhoff L, Simeth NA, Tittmann K.   +4 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

M3Site: multiclass multimodal learning for protein active site identification and classification. [PDF]

Brief Bioinform
Ouyang S, Luo Y, Cai H, Su K, Liao F, Zhan N, Zhao H, Yin T, Zhao L, Shan D.   +9 more
europepmc   +1 more source

Structural flexibility of the methanogenic‐type seryl‐tRNA synthetase active site and its implication for specific substrate recognition [PDF]

, 2008
Silvija Bilokapić, Jasmina Rokov‐Plavec, Nenad Ban, Ivana Weygand-Đurašević   +3 more
openalex   +1 more source

An Ultrasmall Ordered High-Entropy Intermetallic with Multiple Active Sites for the Oxygen Reduction Reaction

, 2023
Tao Chen, Chunyu Qiu, Xinkai Zhang, Hangchao Wang, Song Jin, Kun Zhang, Tonghuan Yang, Yuxuan Zuo, Yali Yang, Chuan Gao, Wukun Xiao, Zewen Jiang, Yucheng Wang, Yan Xiang, Dingguo Xia   +14 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

The Role of Active Site Hydrophobic Interactions in Facilitating Catalysis in Human Terminal Deoxynucleotidyl Transferase. [PDF]

Int J Mol Sci
Senchurova SI, Tyugashev TE, Kuznetsov NA.   +2 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A protective and heterosubtypic antibody lineage targeting the influenza A virus neuraminidase active site. [PDF]

J Clin Invest
Sornberger TA, Wolters RM, Gilchuk IM, Myers L, Binshtein E, Irving R, Chen EC, Gilchuk P, Nargi RS, Sutton RE, Howard BN, Handal LS, Trivette A, Webb KE, Kona C, Villalobos E, Williamson LE, Crowe JE, Zost SJ.   +18 more
europepmc   +1 more source

Nickel amine/imine and amine/amide bisthiolate complexes as models for the active site of nickel superoxide dismutase

, 2018
Nilmini K. Senaratne
openalex   +1 more source