Results 191 to 200 of about 11,841,496 (406)

Active Site of Papain and Covalent “High Energy” Bonds of Proteins

, 1958
Emil L. Smith
openalex   +1 more source

Chemistry of the active site of rhodopsin [PDF]

, 1969
M. Akhtar, M. D. Hirtenstein
openalex   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

PROPERTIES OF THE PHOSPHORYLATED ACTIVE SITE OF PHOSPHOGLUCOMUTASE

, 1957
Eugene P. Kennedy, Daniel E. Koshland
openalex   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Identificación in silico de moléculas potencialmente inhibidoras de CDK5, proteína relacionada con la enfermedad de Alzheimer

Revista Habanera de Ciencias Médicas
RESUMEN Introducción: La enfermedad de Alzheimer exhibe un compromiso neurodegenerativo e irreversible. Hoy, numerosas investigaciones promueven la inhibición de algunas quinasas para su tratamiento, de especial mención la CDK5.
Nerlis Pájaro-Castro, Jesús Bustamante-Díaz, Cristhian Ibáñez-Bersinger   +2 more
doaj  

Druggability analysis and classification of protein tyrosine phosphatase active sites

Drug Design, Development and Therapy, 2016
Mohammad A Ghattas, Noor Raslan, Asil Sadeq, Mohammad Al Sorkhy, Noor Atatreh College of Pharmacy, Al Ain University of Science and Technology, Al Ain, UAE Abstract: Protein tyrosine phosphatases (PTP) play important roles in the pathogenesis of many ...
Ghattas MA, Raslan N, Sadeq A, Al Sorkhy M, Atatreh N   +4 more
doaj  

Properties and Conformation of the Histidine Residues at the Active Site of Ribonuclease

, 1963
Arthur M. Crestfield, William H. Stein, Stanford Moore   +2 more
openalex   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

The sequence around an active‐site aspartyl residue in pepsin [PDF]

, 1968
Jeremy R. Knowles, Grith B. Wybrandt
openalex   +1 more source