Results 201 to 210 of about 4,321,073 (342)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Single-Atom Site Photocatalysts Boosting Organic Synthesis: The Integration of a Metal Active Site and Photosensitive Unit. [PDF]

Nanomaterials (Basel)
Sun H, Yang Y, Liu Y, Yang D, Liu Y, Sun Z.   +5 more
europepmc   +1 more source

Surface Engineering to Tailor the Active Sites of Srti0.9co0.1o3-Δ Perovskite for Co Oxidation

, 2023
JeongHyun Cho, Min-Jae Kim, Kyung Tae Park, Chang Houn Rhee, Hai Woong Park, Bonjae Koo, Ji Chul Jung   +6 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Mutation of a conserved anthranilate phosphoribosyltransferase active site residue supports tryptophan biosynthesis <i>in vivo</i>. [PDF]

MicroPubl Biol
Klepin S, Michalik B, Pillus L, Chik JK.
europepmc   +1 more source

Synthetic Analogues of the Active Site of the A-Cluster of Acetyl Coenzyme A Synthase/CO Dehydrogenase:  Syntheses, Structures, and Reactions with CO

, 2006
Todd C. Harrop, Marilyn M. Olmstead, Pradip K. Mascharak   +2 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Simultaneous occupancy of Cu_C and Cu_D in the ammonia monooxygenase active site. [PDF]

Chem Sci
Tucci FJ, Ho MB, Turner AAB, Stein LY, Hoffman BM, Rosenzweig AC.   +5 more
europepmc   +1 more source

Evidence for essential histidine and dicarboxylic amino-acid residues in the active site of UDP-glucose : solasodine glucosyltransferase from eggplant leaves.

, 2003
Paulina Nawłoka, Małgorzata Kalinowska, Cezary Pączkowski, Zdzisław A. Wojciechowski   +3 more
openalex   +2 more sources

Activating oligomerization as intermediate level of signal transduction: analysis of protein-protein contacts and active sites in several glycolytic enzymes [PDF]

, 1999
I. Yu. Torshin
openalex   +1 more source