Results 201 to 210 of about 11,841,496 (406)

Iron-facilitated dynamic active-site generation on spinel CoAl2O4 with self-termination of surface reconstruction for water oxidation

Nature Catalysis, 2019
Tianze Wu, Shengnan Sun, Jiajia Song, S. Xi, Yonghua Du, Bo Chen, W. A. Sasangka, Hanbin Liao, C. Gan, G. Scherer, L. Zeng, Haijiang Wang, Hui Li, A. Grimaud, Zhichuan J. Xu   +14 more
semanticscholar   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

The Reactivities of the Histidine Residues at the Active Site of Ribonuclease toward Halo Acids of Different Structures

, 1965
Robert L. Heinrikson, William H. Stein, Arthur M. Crestfield, Stanford Moore   +3 more
openalex   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Nucleotide Specificity and Conformation of the Active Site of Creatine Kinase

, 1966
W.J. O’Sullivan, Mildred Cohn
openalex   +1 more source

Evidence of the Presence of 1-Phosphohistidine as the Main Phosphorylated Component at the Active Site of Bovine Liver Nucleoside Diphosphate Kinase. [PDF]

, 1969
Olov Wålinder, Erik von Sydow, Thomas Popoff, Olof Theander, Alf A. Lindberg, Gert Jansen, Bo Lamm, Benny Samuelsson   +7 more
openalex   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

On the Alkylation of Amino Acid Residues at the Active Site of Ribonuclease

, 1966
Robert L. Heinrikson
openalex   +1 more source

THE ACTIVE SITE IN α-CHYMOTRYPSIN: METHYL 3,4-DIHYDROISOCOUMARIN-3-CARBOXYLATE I [PDF]

, 1967
Saul G. Cohen, Richard M. Schultz
openalex   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source