Active site-specific immunoassays [PDF]
Blood, 1990 This study describes a process by which serine proteases that contain an S-1 arginine subsite and active site histidine may be inactivated and subsequently quantitated using a combination of peptidyl chloromethylketone chemistry and immune recognition technology.
K G, Mann +5 more
openaire +3 more sources
Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction. [PDF]
, 2016 Sesquiterpenoids comprise a class of terpenoid natural products with thousands of compounds that are highly diverse in structure, generally containing a polycyclic carbon backbone that is constructed by a sesquiterpene synthase.
Bertolani, SJ +3 more
core +2 more sources
Gasification under CO2–Steam Mixture: Kinetic Model Study Based on Shared Active Sites
Energies, 2017 In this work, char gasification of two coals (i.e., Shenfu bituminous coal and Zunyi anthracite) and a petroleum coke under a steam and CO2 mixture (steam/CO2 partial pressures, 0.025–0.075 MPa; total pressures, 0.100 MPa) and CO2/steam chemisorption of ...
Xia Liu +3 more
doaj +1 more source
Identification of the catalytic motif of the microbial ribosome inactivating cytotoxin colicin E3 [PDF]
, 2004 Colicin E3 is a cytotoxic ribonuclease that specifically cleaves 16S rRNA at the ribosomal A-site to abolish protein synthesis in sensitive Escherichia coli cells.
Bohm +30 more
core +2 more sources
Analysis of Binding Site Hot Spots on the Surface of Ras GTPase [PDF]
, 2011 We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers.
Buhrman, Greg +9 more
core +2 more sources
Understanding of Active Sites and Interconversion of Pd and PdO during CH4 Oxidation
Molecules, 2023 Pd-based catalysts are widely used in the oxidation of CH4 and have a significant impact on global warming. However, understanding their active sites remains controversial, because interconversion between Pd and PdO occurs consecutively during the ...
Dong Gun Oh +6 more
doaj +1 more source
Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1. [PDF]
, 2017 In the human sodium glucose cotransporter (hSGLT1) cycle, the protein undergoes conformational changes where the sugar-binding site alternatively faces the external and internal surfaces.
Gorraitz, Edurne +4 more
core +2 more sources
Фармация и фармакология (Пятигорск), 2017 Nowadays cardiovascular diseases are the main cause of death among the population around the word. The development of new drugs, giving a possibility to normalize blood pressure, is a promising direction in the field of pharmacy and medicine.
A. A. Glushko +4 more
doaj +1 more source
Metagenomic characterization of sphingomyelinase C in the microbiome of humans and environments
Frontiers in Cellular and Infection Microbiology, 2022 Bacterial sphingomyelinases (SMases) hydrolyze sphingomyelin and play an important role in membrane dynamics and the host immune system. While the number of sequenced genomes and metagenomes is increasing, a limited number of experimentally validated ...
Jehyun Jeon +7 more
doaj +1 more source
Insights Into the Carboxyltransferase Reaction of Pyruvate Carboxylase From the Structures of Bound Product and Intermediate Analogs [PDF]
, 2013 Pyruvate carboxylase (PC) is a biotin-dependent enzyme that catalyzes the MgATP- and bicarbonate-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in central metabolism.
Lietzan, Adam D., Maurice, Martin St.
core +2 more sources