Results 291 to 300 of about 11,841,496 (406)

Extreme electric fields power catalysis in the active site of ketosteroid isomerase

Science, 2014
S. Fried, Sayan Bagchi, S. Boxer
semanticscholar   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

The conserved active site aspartate residue is required for the function of the chloroplast atypical kinase ABC1K1. [PDF]

Front Plant Sci
Turquand M, Justo Da Silva AR, Pralon T, Longoni F, Kessler F, Collombat J.   +5 more
europepmc   +1 more source

Enhanced Enzyme Kinetic Stability by Increasing Rigidity within the Active Site*

Journal of Biological Chemistry, 2014
Yuan Xie, Jiao An, Guangyu Yang, Geng Wu, Yong Zhang, Li Cui, Yan Feng   +6 more
semanticscholar   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Magnesium induced structural reorganization in the active site of adenylate kinase. [PDF]

Sci Adv
Nam K, Thodika ARA, Tischlik S, Phoeurk C, Nagy TM, Schierholz L, Ådén J, Rogne P, Drescher M, Sauer-Eriksson AE, Wolf-Watz M.   +10 more
europepmc   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

A crucial active site network of titratable residues guides catalysis and NAD⁺ binding in human succinic semialdehyde dehydrogenase. [PDF]

Protein Sci
Cesaro S, Orlando M, Bettin I, Longo C, Spagnoli G, de Laureto PP, Molla G, Bertoldi M.   +7 more
europepmc   +1 more source

The Tertiary Structures of Proteolytic Enzymes and their Active Sites

, 1967
Yǔji Inada
openalex   +2 more sources

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source