Results 311 to 320 of about 11,841,496 (406)

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Conformational Flexibility of the C-Terminal Region Influences Distal Active Site Residues Across the Tautomerase Superfamily. [PDF]

Int J Mol Sci
Argueta C, Parkins A, Pantouris G.
europepmc   +1 more source

Intestinal surface amino-oligopeptidases. II. Substrate kinetics and topography of the active site.

, 1977
Renate Kania, Nilda A. Santiago, Gary M. Gray   +2 more
openalex   +1 more source

Remarkable Active Site Utilization in Edge-Hosted-N Doped Carbocatalysts for Fenton-Like Reaction. [PDF]

Adv Sci (Weinh)
Zhong H, Gong Z, Yu J, Hou Y, Tao Y, Fu Q, Yang H, Xiao X, Cao X, Wang J, Ouyang G.   +10 more
europepmc   +1 more source

Tryptophan in the Active Site of Rhodanese

Journal of Biological Chemistry, 1965
Betty Davidson, John Westley
openaire   +3 more sources

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Is Fe the Most Active Site for Fe/N-Doped Graphdiyne? [PDF]

ACS Omega
Feng Y, Sun M, Ji Y, Fan T.
europepmc   +1 more source

Evidence for an Aspartyl Phosphate Residue at the Active Site of Sodium and Potassium Ion Transport Adenosine Triphosphatase

, 1973
Robert L. Post, Shoji Kume
openalex   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Functional Identification and Regulatory Active Site Screening of the DfDXS Gene of Dryopteris fragrans. [PDF]

Plants (Basel)
Zhao H, Su J, Zhong Z, Xiong T, Dai W, Zhang D, Chang Y.   +6 more
europepmc   +1 more source