Results 31 to 40 of about 4,321,073 (342)

Active-Site-Directed Inhibitors of Prolyl Oligopeptidase Abolish Its Conformational Dynamics [PDF]

, 2016
Deciphering conformational dynamics is crucial for understanding the biological functions of proteins and for designing compounds targeting them. In particular, providing an accurate description of microsecond–millisecond motions opens the opportunity ...
Bernadó, Bernadó, Boehr, Brandt, Canning, Cunningham, Delaglio, Di Daniel, Fülöp, Gelis, Henzler-Wildman, Hornak, Jacques, Jaeger, Jorgensen, Kaszuba, Kichik, Konarev, Korzhnev, Li, Mertens, Mulder, Myöhänen, Nevola, Palmer, Religa, Savolainen, Savolainen, Shan, Svergun, Svergun, Tarragó, Tugarinov, Venäläinen, Yoshimoto   +34 more
core   +3 more sources

Protein aggregates nucleate ice: the example of apoferritin [PDF]

, 2020
Biological material has gained increasing attention recently as a source of ice-nucleating particles that may account for cloud glaciation at moderate supercooling.
Bittner, Alexander M., Cascajo-Castresana, María, David, Robert O., Iriarte-Alonso, Maiara A., Marcolli, Claudia   +4 more
core   +1 more source

Exploring the possibility of chemisorption of ethylene on graphene with and without defects [PDF]

Polyolefins Journal, 2023
The effect of structural defects on graphene interaction with other molecules is of high interest. In this study, the interaction of ethylene molecules with pristine graphene (PG) and defective graphenes including single (SVG) and double (DVG) vacancies,
Parisa Alamdari, Farhad Sharif, Saeedeh Mazinani   +2 more
doaj   +1 more source

ARIA 2016 : Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle [PDF]

, 2016
European Innovation Partnership on Active and Healthy Ageing Reference Site MACVIA-France, EU Structural and Development Fund Languedoc-Roussillon, ARIA.Peer reviewedPublisher ...
Agache, I, Bachert, C., Bedbrook, A., Bergmann, K. C., Bousquet, J, Hellings, P. W., Price, D.   +6 more
core   +1 more source

Potential Adiponectin Receptor Response Modifier Therapeutics

Frontiers in Endocrinology, 2019
Many human diseases may benefit from adiponectin replacement therapy, but due to pharmacological disadvantages of the intact protein, druggable options focus on peptidic, and small molecule agonists of the adiponectin receptor.
Laszlo Otvos, Laszlo Otvos, Laszlo Otvos
doaj   +1 more source

Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15. [PDF]

, 2010
The crystal structure of a putative NTPase, YP_001813558.1 from Exiguobacterium sibiricum 255-15 (PF09934, DUF2166) was determined to 1.78 Å resolution. YP_001813558.1 and its homologs (dimeric dUTPases, MazG proteins and HisE-encoded phosphoribosyl ATP ...
Abdubek, Polat, Astakhova, Tamara, Axelrod, Herbert L, Carlton, Dennis, Chen, Connie, Chiu, Hsiu Ju, Clayton, Thomas, Das, Debanu, Deacon, Ashley M, Deller, Marc C, Duan, Lian, Elsliger, Marc André, Ernst, Dustin, Feuerhelm, Julie, Godzik, Adam, Grant, Joanna C, Grzechnik, Anna, Han, Gye Won, Hodgson, Keith O, Jaroszewski, Lukasz, Jin, Kevin K, Johnson, Hope A, Klock, Heath E, Knuth, Mark W, Kozbial, Piotr, Krishna, S Sri, Kumar, Abhinav, Lam, Winnie W, Lesley, Scott A, Marciano, David, McMullan, Daniel, Miller, Mitchell D, Morse, Andrew T, Murzin, Alexey G, Nigoghossian, Edward, Okach, Linda, Reyes, Ron, Rife, Christopher L, Sefcovic, Natasha, Tien, Henry J, Trame, Christine B, van den Bedem, Henry, Weekes, Dana, Wilson, Ian A, Wooley, John, Xu, Qingping, Yeates, Todd O   +46 more
core   +2 more sources

Identification of single-site gold catalysis in acetylene hydrochlorination [PDF]

, 2017
There remains considerable debate over the active form of gold under operating conditions of a recently validated gold catalyst for acetylene hydrochlorination.
Catlow, C. Richard A., Davies, Catherine J., Dawson, Simon, Freakley, Simon J., Gibson, Emma K., Hutchings, Graham J., Johnston, Peter, Jones, Wilm, Kiely, Christopher J., Kondrat, Simon A., Lu, Li, Malta, Grazia, Morgan, David J., Thetford, Adam, Wells, Peter P.   +14 more
core   +4 more sources

13C-Methyl isocyanide as an NMR probe for cytochrome P450 active site [PDF]

, 2009
The cytochromes P450 (CYPs) play a central role in many biologically important oxidation reactions, including the metabolism of drugs and other xenobiotic compounds.
Im, Sang-Choul, McCullough, Christopher R, Pullela, Phani Kumar, Sem, Daniel S., Waskell, Lucy   +4 more
core   +2 more sources

Two Sides of Quantum-Based Modeling of Enzyme-Catalyzed Reactions: Mechanistic and Electronic Structure Aspects of the Hydrolysis by Glutamate Carboxypeptidase

Molecules, 2021
We report the results of a computational study of the hydrolysis reaction mechanism of N-acetyl-l-aspartyl-l-glutamate (NAAG) catalyzed by glutamate carboxypeptidase II.
Alexandra V. Krivitskaya, Maria G. Khrenova, Alexander V. Nemukhin   +2 more
doaj   +1 more source

Redox-active ferrocene-modified Cowpea mosaic virus nanoparticles [PDF]

, 2010
A naturally occurring nanoparticle, the plant virus Cowpea mosaic virus, can be decorated with ferrocene derivatives, of various linker lengths with amine and carboxylategroups, on the external surface using a range of conjugation strategies.
Alaa A. A. Aljabali, Astruc, Beasley, Chatterji, Chidsey, Constable, David J. Evans, Evans, Evans, Frederix, George P. Lomonossoff, Green, J. Elaine Barclay, Julea N. Butt, Lin, Lomonossoff, Lopez, Molina, Newkome, Padeste, Steinmetz, Steinmetz, Steinmetz, Togni, Wang, Wang, Wellink, Yang, Yang   +28 more
core   +1 more source