Results 71 to 80 of about 1,610,463 (321)

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

Fenton’s reagent-initiated modification of plantain (Musa paradisiaca) peel biomass – mechanisms of chain propagation and dyes removal from simulated wastewaters [PDF]

open access: yesJournal of Chemistry Letters
This report describes the mechanisms of Fenton’s reagent-initiated graft-copolymerization of plantain peel biomass (PPB) and that of the polymer-dyes interactions. Methacrylic acid (MAA) was grafted onto the PPB backbone.
Vincent Oninla   +6 more
doaj   +1 more source

Evolutionary dynamics in the Bak-Sneppen model on small-world networks [PDF]

open access: yesarXiv, 1999
We study the dynamics of the Bak-Sneppen model on small-world networks. For each site in the network, we define a ``connectance,'' which measures the distance to all other sites. We find radically different patterns of activity for different sites, depending on their connectance and also on the topology of the network.
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date

open access: yesMolecules, 2017
The cytochrome P450 (CYP) family 1A enzymes, CYP1A1 and CYP1A2, are two of the most important enzymes implicated in the metabolism of endogenous and exogenous compounds through oxidation.
Jayalakshmi Sridhar   +3 more
doaj   +1 more source

Stochastic Models of User-Contributory Web Sites [PDF]

open access: yesProc. of the 3rd Intl Conf on Weblogs and Social Media (ICWSM2009), pp. 50-57 (2009), 2009
We describe a general stochastic processes-based approach to modeling user-contributory web sites, where users create, rate and share content. These models describe aggregate measures of activity and how they arise from simple models of individual users.
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Shedding Light on the Active Species in a Cobalt‐Based Covalent Organic Framework for the Electrochemical Oxygen Evolution Reaction

open access: yesAdvanced Science
While considerable efforts have been devoted to developing functionalized covalent organic frameworks (COFs) as oxygen evolution electrocatalysts in recent years, studies related to the investigation of the true catalytically active species for the ...
Pouya Hosseini   +7 more
doaj   +1 more source

Effect of buoyancy on fingering growth activity in immiscible two-phase flow displacements

open access: yesJournal of Fluid Science and Technology, 2018
Immiscible displacement processes have been investigated for decades to understand their applications, such as geosequestration of CO2 and enhanced oil recovery, in detail.
Mushlih MUHARRIK   +2 more
doaj   +1 more source

Histidine residues at the copper-binding site in human tyrosinase are essential for its catalytic activities

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2020
Tyrosinase is a copper-binding enzyme involved in melanin biosynthesis. However, the detailed structure of human tyrosinase has not yet been solved, along with the identification of the key sites responsible for its catalytic activity.
Hyangsoon Noh   +5 more
doaj   +1 more source

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