Results 1 to 10 of about 1,259,380 (310)
Foods, 2022 In this study, the comparison effects of ultrasound-assisted immersion freezing (UIF) at different ultrasonic power, immersion freezing (IF), and air freezing (AF) on the protein thermal stability, protein structure, and physicochemical properties of ...
Bing Liu +4 more
doaj +1 more source
Discovery of Novel Biphenyl Carboxylic Acid Derivatives as Potent URAT1 Inhibitors
Molecules, 2023 Urate transporter 1 (URAT1) is a clinically validated target for the treatment of hyperuricemia and gout. Due to the absence of protein structures, the molecular design of new URAT1 inhibitors generally resorts to ligand-based approaches.
Xianxin Hou +3 more
doaj +1 more source
Three-Step Synthesis of the Antiepileptic Drug Candidate Pynegabine
Molecules, 2023 Pynegabine, an antiepileptic drug candidate in phase I clinical trials, is a structural analog of the marketed drug retigabine with improved chemical stability, strong efficacy, and a better safety margin.
Yi-Jing Sun +4 more
doaj +1 more source
Toxins, 2022 The venom and transcriptome profile of the captive Chinese cobra (Naja atra) is not characterized until now. Here, LC-MS/MS and illumine technology were used to unveil the venom and trascriptome of neonates and adults N. atra specimens.
Xuekui Nie +7 more
doaj +1 more source
Strategies and Efforts towards the Total Synthesis of Palhinine Alkaloids
Molecules, 2020 The palhinine family of Lycopodium alkaloids were first reported in 2010, which feature an intriguing isotwistane carbon cage and a nine-membered azonane ring.
Yu-Yan Liang +3 more
doaj +1 more source
Statement on the active substance flupyradifurone [PDF]
EFSA Journal, 2022 Flupyradifurone is a novel butenolide insecticide, first approved as an active substance for use in plant protection products by Commission Implementing Regulation (EU) 2015/2084. Following concerns that this substance may pose high risks to humans and the environment, the French authorities, in November 2020, asked the Commission to restrict its uses ...
EFSA Panel on Plant Protection Products and their Residues (PPR) +22 more
openaire +4 more sources
Molecules, 2022 C4 variation of 4′-O-demethyl-epipodophyllotoxin (DMEP) is an effective approach to optimize the antitumor spectra of this compound class. Accordingly, two series of novel DMEP derivatives were synthesized, and as expected, the antitumor spectra of these
Wenli Xi +4 more
doaj +1 more source
Excessive alcohol consumption in young men: is there an association with their earlier family situation? A baseline-analysis of the C-SURF-study (Cohort Study on Substance Use Risk Factors). [PDF]
, 2014 AIMS: To determine whether parental factors earlier in life (parenting, single parent family, parental substance use problem) are associated with patterns of alcohol consumption among young men in Switzerland. METHODS: This analysis of a population based
Gmel, G., Schori, D., Steiner, S.
core +1 more source
Statement on the active substance acetamiprid [PDF]
EFSA Journal, 2022 Acetamiprid is a pesticide active substance with insecticidal action currently under the third renewal (AIR3) of the Commission implementing regulation (EU) No 844/2012. Following concerns that this substance may pose high risks to humans and the environment, the French authorities asked the Commission to restrict its uses under Article 69 of ...
EFSA Panel on Plant Protection Products and their Residues (PPR) +22 more
openaire +5 more sources
Importance of understanding variable and transient energy demand in large multi-product industrial plants for process integration [PDF]
, 2011 There have been some news releases claiming that Professor Henle in Germany has found the chemical identity of UMF, and that in future chemical analysis will be used instead of assays of antibacterial activity to indicate the level of UMF in manuka honey.
Atkins, Martin John +3 more
core +2 more sources