Results 61 to 70 of about 1,259,380 (310)
EFSA Journal, 2023 Plant Protection Products, also called ‘pesticides’, are intended to protect crops by controlling pests, weeds and diseases. This Technical Report contains a description of the activities within the work programme of the EU‐FORA Fellowship on the ...
Nicole Cilia, Ioannis Kandris
doaj +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Chemical analysis of substitute drugs of abuse – “legal highs” from Lubuskie province, Poland
Journal of Medical Science, 2014 Introduction. Interest in substitute drugs of abuse, commonly called “dopalacze” [literally “after-burns”] that is “legal highs”, in Poland and abuse of such products, which could pose a significant life hazard, led to legislative action taken by the ...
Kinga Mruczyk +4 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Switchable Site-Selective Benzanilide C(sp2)-H Bromination via Promoter Regulation
MoleculesRegioselective benzanilide bromination that generates either regioisomer from the same starting material is desirable. Herein, we develop switchable site-selective C(sp2)-H bromination by promoter regulation.
Yonghui Sun +6 more
doaj +1 more source
Using a Social Entrepreneurial Model to Treat Substance Abuse: Triangle Residential Option for Substance Abusers (TROSA) [PDF]
, 2005 At the Triangle Residential Option for Substance Abusers (TROSA), a North Carolina residential treatment program, Executive Director Kevin McDonald and his colleagues have advanced a social entrepreneurial model for nearly a decade.
Jonathan Walters
core
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Molecules, 2014 Clofazimine, a member of the riminophenazine class, is one of the few antibiotics that are still active against multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis).
Dongfeng Zhang +11 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source