Results 71 to 80 of about 376,531 (312)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Synthesis and Biological Evaluation of Novel 2-Methoxypyridylamino-Substituted Riminophenazine Derivatives as Antituberculosis Agents

Molecules, 2014
Clofazimine, a member of the riminophenazine class, is one of the few antibiotics that are still active against multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis).
Dongfeng Zhang, Yang Liu, Chunlin Zhang, Hao Zhang, Bin Wang, Jian Xu, Lei Fu, Dali Yin, Christopher B. Cooper, Zhenkun Ma, Yu Lu, Haihong Huang   +11 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Species-specific efficacy of the active substance of the 1904–1 extract.

, 2015
Efficacy of species-specificities of the active substance of the 1904–1 extract was studied. M. smegmatis was cultured in the media containing serial dilutions of the 1904-1-derived active substance.
Mamiko Niki (217183), Yukiko Nishiuchi (217180), Yoshitaka Tateishi (167290), Ryuichi Sawa (827420), Shymaa Enany (827422), Mayuko Osada-Oka (217170), Masayuki Igarashi (827417), Masaki Hatano (827423), Yuriko Ozeki (257573), Maya Umekita (827421), Sohkichi Matsumoto (217214), Aki Tamaru (257583), Tetsuya Hayashi (45299), Matsumi Doe (827418), Naoko Kinoshita (827419), Tomotada Iwamoto (118148), Yoshitoshi Ogura (45290)   +16 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

I Did What Last Night? Adolescent Risky Sexual Behaviors and Substance Abuse [PDF]

Risky sexual behaviors by teenagers have shown to be strongly correlated with drug and alcohol consumption. The purpose of this study is to examine the question of whether alcohol and drug use increases the likelihood that teenagers will engage in four ...
Michael Grossman, Sarah Markowitz
core  

Susceptibility testing of resistant BCG mutants to the active substance of 1904–1.

, 2015
Three BCG strains resistant to the active substance of the 1904–1 extract were obtained by selection on agar containing the substance and are designated as 4, 9, and 20.
Mamiko Niki (217183), Yukiko Nishiuchi (217180), Yoshitaka Tateishi (167290), Ryuichi Sawa (827420), Shymaa Enany (827422), Mayuko Osada-Oka (217170), Masayuki Igarashi (827417), Masaki Hatano (827423), Yuriko Ozeki (257573), Maya Umekita (827421), Sohkichi Matsumoto (217214), Aki Tamaru (257583), Tetsuya Hayashi (45299), Matsumi Doe (827418), Naoko Kinoshita (827419), Tomotada Iwamoto (118148), Yoshitoshi Ogura (45290)   +16 more
core   +1 more source

Unexpected Discovery of Structure‐dependent Aggregation of N‐Oxide Enables Novel Heme‐detecting Probes

Aggregate
N‐oxides, characterized by a highly polar N+–O− bond, have recently demonstrated rapidly growing applications in biomedicine and material science due to their high solubility and redox activity.
Si Ha, Tingyu Guo, Pengfei Lei, Yuting Zhang, Hong Zhang, Feifei Kong, Jing Li, Zhuo Li, Xiang Lv, Chong‐Jing Zhang   +9 more
doaj   +1 more source

Application of macro-fungi additives in livestock and poultry production

Siliao yanjiu, 2021
Macro-fungi contains polysaccharides, polyacetylenes, terpenoids, phenols and other biologically active substances. The active ingredients have good nutritional and pharmacological value, which can improve animal's ability to resist oxidation ...
Tao HUANG
doaj