Results 191 to 200 of about 334,918 (302)

A Dual‐Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Liquid biopsy technology, which detects circulating tumor DNA (ctDNA) in cerebrospinal fluid, plays a crucial role in the early diagnosis and precision treatment of gliomas. However, the intrinsically low abundance and rapid clearance of ctDNA pose substantial challenges for conventional analytical techniques, such as droplet digital PCR and ...
Yu Sun, Jing Zhang, Chenqing Liu, Jing Lou, Sihui Wang, Xiangtian Ji, Xiaofang Zhao, Shirui Xu, Jingyu Feng, Bin Liu, Chao Chang, Qinggang Ge, Jun Yang   +12 more
wiley   +1 more source

Application of the STRATCANS Criteria to the MUSIC Prostate Cancer Active Surveillance Cohort: A Step Towards Risk-Stratified Active Surveillance. [PDF]

Cancers (Basel)
Moser AM, Wang M, Zamani A, Meah S, Daignault-Newton S, Labardee C, Dybas N, Clapper J, Lane BR, Borza T, Semerjian A, Gnanapragasam VJ, Ginsburg KB.   +12 more
europepmc   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Evidence based targeting of districts for active surveillance of skin-related neglected tropical diseases in Ghana. [PDF]

PLOS Glob Public Health
Jones-Warner W, Amoako YA, Opare J, Kotey NK, Yeboah-Manu D, Phillips RO, Pullan R, Simpson H.   +7 more
europepmc   +1 more source

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

Integrating active surveillance and HPV vaccination for high-risk CIN2: a strategy to reduce disease progression. [PDF]

Front Med (Lausanne)
Geng K, Bai S, Liu R, Jia L, Zhai Y, Sun Z, Jiao R, Li X, Liu J, Bai H.   +9 more
europepmc   +1 more source

Testing a Cloud-Based Model for Active Surveillance of Medical Devices with Analyses of Coronary Stent Safety Using the Data Extraction and Longitudinal Trend Analysis (DELTA) System

Joseph P Drozda Jr,1,* Henry Ssemaganda,2,* Edward A Frankenberger,3,* Eric Brandt,4,* Susan Robbins,2,* Neha Khairnar,2,* Alexandra Cha,5,* Frederic S Resnic6,* 1Retiree, Mercy, Chesterfield, MO, USA; 2Comparative ...
Frankenberger EA, Robbins S, Brandt E, Khairnar N, Ssemaganda H, Drozda JP Jr, Resnic FS, Cha A   +7 more
core  

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Patient-reported outcomes: active surveillance vs radical therapies in low-risk prostate cancer. [PDF]

BJU Int
Al-Nader M, Kesch C, Mahmoud O, Hadaschik BA, Fichtner J, Carl G, Feick G, Burchardt M, Zimmermanns V, Prause L, Polat B, Blana A, Horstmann M, Saar M, Miglierini P, Almansur K, Hefermehl L, Porres D, Peters I, Wiens K, Palisaar RJ, Winter A, Neisius A, Kunzmann EM, Harke NN, Bolenz C, Albarghouth MH, Manka L, Kramer M, Luger F, Knoll T, Pfitzenmaier J, Brock M, Schittko J, Sommer JP, Reichert M, Lenart S, Huber P, Hijazi S, Calderaro A, Hermanns T, Tonhauser J, Kowalski C, Sibert NT.   +43 more
europepmc   +1 more source