Results 201 to 210 of about 334,918 (302)

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

The Impact of Endpoint Definitions on Predictors of Progression in Active Surveillance for Early Prostate Cancer. [PDF]

Cancers (Basel)
Sandhu K, Lophatananon A, Gnanapragasam VJ.   +2 more
europepmc   +1 more source

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor‐Draining Lymph Nodes of Breast Cancer

Advanced Science, EarlyView.
This study develops an intelligent NIR‐II‐responsive nanoplatform to combat immunosuppression in breast cancer. It enables real‐time visualization of macrophage activity via “off‐on” fluorescence while simultaneously reprogramming macrophages through the CSF‐1R and CD47‐SIRPα pathways.
Yingbo Li, Di Chang, Jie Yang, Ying Bai, Min Chen, Daoshuang Li, Zuoyu Xu, Jiaxin Yuan, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Zixin Chen, Jinbing Xie, Zebin Xiao, Shenghong Ju   +14 more
wiley   +1 more source

Synolitic Graph Neural Networks for MRI-Derived Radiomic-Based Prediction of Prostate Cancer Progression on Active Surveillance. [PDF]

Cancers (Basel)
Krivonosov MI, Trukhanov A, Sushentsev N, Barrett T, Zaikin A.   +4 more
europepmc   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Variation in prostate cancer growth rates in an MRI-based active surveillance cohort. [PDF]

Eur Radiol
Smith H, Stavrinides V, Giganti F, Moore CM, Narayanan B, Emberton M, Pharoah PDP, Pashayan N.   +7 more
europepmc   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Post-Marketing Active Surveillance of Adverse Events Following Quadrivalent Subunit Influenza Vaccine in Healthy Participants Aged ≥ 3 Years in China. [PDF]

Infect Dis Ther
Wei M, Pan Y, Wang K, Li M, Tang S, Huang Q, Chen H, Kou Z, Xie N, Guo X, An J, Zhang J, Kezhong A, Chen Y, An Y, Kang L, Tao H, Pan H.   +17 more
europepmc   +1 more source

Metasurface‐Enabled Active‐Like Passive Radar

Advanced Science, EarlyView.
A programmable space‐time‐coding metasurface embeds distinct spatiotemporal tags into ambient wireless signals, allowing passive radar to operate in an active‐like manner. By enabling code‐correlated reconstruction under interference, the approach supports robust real‐time UAV tracking in complex environments and points to intelligent, low‐power ...
Mingyi Li, Jiawen Xu, Hanting Zhao, Xu Zhao, Yanjin Chen, Tie Jun Cui, Vincenzo Galdi, Lianlin Li   +7 more
wiley   +1 more source

Investigating Associations Between Psychological Distress and Changes in Peripheral Blood Monocytes in Patients With CLL/SLL Managed With Active Surveillance. [PDF]

Cancer Med
Fang CY, MacFarlane AW, Fung HCH, Khan N, Barta SK, Hasler JS, Ballard HJ, Landsburg DJ, Nasta SD, Schuster SJ, Khanal R, Fisher RI, Cohen AD, Svoboda J, Campbell KS.   +14 more
europepmc   +1 more source