Results 41 to 50 of about 334,918 (302)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Active Vaccine Safety Surveillance: Global Trends and Challenges in China

Health Data Science, 2021
Importance. The great success in vaccine-preventable diseases has been accompanied by vaccine safety concerns. This has caused vaccine hesitancy to be the top 10 in threats to global health.
Zhike Liu, Ruogu Meng, Yu Yang, Keli Li, Zundong Yin, Jingtian Ren, Chuanyong Shen, Zijian Feng, Siyan Zhan   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Active surveillance for prostate cancer: Is it ready for primetime in the Caribbean?

African Journal of Urology, 2017
Objective: In this paper we discuss the strategy of active surveillance (AS) as a whole followed by the implications of its use in the Caribbean. Methods: The literature was reviewed with a view to establishing the merits of AS and to identify potential ...
S. Persaud, L. Goetz, A.L. Burnett
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Active surveillance for nonmuscle invasive bladder cancer [PDF]

Investigative and Clinical Urology, 2016
Nonmuscle invasive bladder cancer (NMIBC) is known to be a heterogeneous malignancy that requires varying treatment modalities and follow-up schedules. Low-grade Ta papillary tumors are categorized as low-risk NMIBC because of their favorable prognosis.
Makito Miyake, Kiyohide Fujimoto, Yoshihiko Hirao   +2 more
doaj   +1 more source

Video surveillance for aircraft activity monitoring [PDF]

Proceedings. IEEE Conference on Advanced Video and Signal Based Surveillance, 2005., 2006
This paper presents a complete visual surveillance system for the automatic scene interpretation of airport aprons. The system comprises two modules scene tracking and scene understanding. The scene tracking module, comprising a bottom-up methodology, and the scene understanding module, comprising a video event representation and recognition scheme ...
Borg, Mark, Thirde, David, Ferryman, James, Fusier, Florent, Valentin, Valery, Bremond, François, Thonnat, Monique   +6 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Long-term Surveillance Outcomes of Prostate Cancer Patients Eligible for Active Surveillance but Who Underwent Radical Prostatectomy

Journal of Urological Surgery
Objective: We aimed to investigate the long-term surveillance outcomes (biochemical recurrance, survival) and adequacy of active surveillance criteria to detect low-risk prostate cancer patients who were eligible for active surveillance but underwent ...
Şakir Ongün, Alper Ege Sarıkaya, Seyit Halil Batuhan Yılmaz, Baran Sevgi, Serdar Çelik, Volkan Şen, Burçin Tuna, Kutsal Yörükoğlu, Güven Aslan, Mehmet Uğur Mungan, İlhan Çelebi   +10 more
doaj   +1 more source