Results 71 to 80 of about 610,101 (198)

Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells. [PDF]

PLoS ONE, 2013
The G-protein coupled receptor (GPCR), Cysteine (C)-X-C Receptor 4 (CXCR4), plays an important role in prostate cancer metastasis. CXCR4 is generally regarded as a plasma membrane receptor where it transmits signals that support transformation ...
Ayesha S Don-Salu-Hewage, Siu Yuen Chan, Kathleen M McAndrews, Mahandranauth A Chetram, Michelle R Dawson, Danaya A Bethea, Cimona V Hinton   +6 more
doaj   +1 more source

Regulation of nuclear actin levels and MRTF/SRF target gene expression during PC6.3 cell differentiation

bioRxiv, 2022
Actin has important functions in both cytoplasm and nucleus of the cell, with active nuclear transport mechanisms maintaining the cellular actin balance.
Salla Kyheröinen, A. Hyrskyluoto, M. Sokolova, M. Vartiainen   +3 more
semanticscholar   +1 more source

Agent-Based Modeling of Intracellular Transport

, 2011
We develop an agent-based model of the motion and pattern formation of vesicles. These intracellular particles can be found in four different modes of (undirected and directed) motion and can fuse with other vesicles. While the size of vesicles follows a
A. Dautry-Varsat, A.-T. Dinh, A.-T. Dinh, F. Schweitzer, F. Schweitzer, G. Doherty, G. Hannon, J. Mercer, M. Birbaumer, M. Marsh, M. Roth, P.D. Fiore, R. Mach, S. Conner, W. Ebeling, W. Ebeling   +15 more
core   +1 more source

The protozoan nucleus [PDF]

, 2016
The nucleus is arguably the defining characteristic of eukaryotes, distinguishing their cell organisation from both bacteria and archaea. Though the evolutionary history of the nucleus remains the subject of debate, its emergence differs from several ...
McCulloch, Richard, Navarro, Miguel
core   +1 more source

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential [PDF]

, 2016
The Karyopherin superfamily is a major class of soluble transport receptors consisting of both import and export proteins. The trafficking of proteins involved in transcription, cell signalling and cell cycle regulation among other functions across the ...
Aggarwal, Albee, Alnabulsi, Alshareeda, Altan, Angus, Behrens, Bernis, Blower, Brinkmann, Brinkmann, Cansizoglu, Chang, Christiansen, Dahl, Das, Dasso, Depping, Dikovskaya, Forbes, Gluz, Gontan, Gorlich, Gousias, Gousias, Gousias, Grupp, Gruss, Hashimoto, Hintersteiner, Hu, Huang, Huang, Huang, Hutchins, Hügel, Ishizawa, Jensen, Jiang, Kahle, Kau, Kazim, Kim, Kimura, King, Knauer, Kojima, Kosugi, Kudo, Kurisaki, Kutay, Kuusisto, Kuusisto, Lapalombella, Latvia, Lau, Laurila, Li, Liang, Liao, Lin, Lin, Lorenzato, Ma, Marfori, Martens-de Kemp, Melo, Mortezavi, Mosammaparast, Muller, Nevins, Noske, Parikh, Poon, Pumroy, Quan, Quensel, Rensen, Sakai, Scherf, Shen, Shi, Shiraki, Sillje, Smith, Smith, Soderholm, Song, Stawerski, Stella Tsai, Stewart, Tai, Torgerson, Turner, Turner, Wagstaff, Wang, Wang, Wang, Watt, Watt, Watt, Wellmann, Wiese, Winkler, Winnepenninckx, Wu, Yan, Yang, Yao, Yoshitake, Yu, Zender, Zheng, Zhou, Zhu, Zhu, Zienkiewicz   +117 more
core   +1 more source

Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress [PDF]

, 2014
Accepted: 8 January 2014 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Acknowledgments
Alfonso, Amparo, Alonso, Eva, Botana, Luis M, Ebel, Rainer, Houssen, Wael E, Jaspars, Marcel, Leirós, Marta, Rateb, Mostafa E, Rateb, Mostafa Ezzat Mohamed, Sánchez, Jon A   +9 more
core   +4 more sources

Nuclear Export of Map Kinase (ERK) Involves a Map Kinase Kinase (Mek-Dependent) Active Transport Mechanism

Journal of Cell Biology, 2000
In response to extracellular stimuli, mitogen-activated protein kinase (MAPK, also known as ERK), which localizes to the cytoplasm in quiescent cells, translocates to the nucleus and then relocalizes to the cytoplasm again.
Makoto Adachi, M. Fukuda, E. Nishida
semanticscholar   +1 more source

A Stochastic Compartmental Model for Fast Axonal Transport [PDF]

, 2011
In this paper we develop a probabilistic micro-scale compartmental model and use it to study macro-scale properties of axonal transport, the process by which intracellular cargo is moved in the axons of neurons.
McKinley, Scott A., Popovic, Lea, Reed, Michael C.   +2 more
core   +1 more source

Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA

Journal of Cell Biology, 1992
Nuclear transport of the U1 snRNP-specific protein U1A has been examined. U1A moves to the nucleus by an active process which is independent of interaction with U1 snRNA.
C. Kambach, I. Mattaj
semanticscholar   +1 more source

RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes [PDF]

, 2013
The role of the mRNA-binding protein human antigen R (HuR) in stabilization and translation of AU-rich elements (ARE) containing mRNAs is well established.
Doller, Anke, Eberhardt, Wolfgang, Pfeilschifter, Josef Martin, Schulz, Sebastian   +3 more
core   +1 more source