Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Other title: Kansas Department of Transportation 101; Other title: [Transportation Overview]
, 2017 "January 24, 2017." Title supplied by the Kansas Department of Transportation website. Alternate title supplied by cataloger.; Presentation before the Kansas Legislature, House Committee on Transportation, presented by the Kansas Department of ...
Kansas. Department of Transportation.
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Neighborhood environment associations with children's active transportation and location-specific physical activity in small town and rural Midwestern settings. [PDF]
J Transp HealthJiang Q +6 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Evaluating the implementation of active transportation infrastructure during the pandemic: a RE-AIM study. [PDF]
BMC Public HealthMonfaredi Z +5 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Prevalence and correlates of active transportation to campus among Canadian post-secondary students: evidence from the Canadian Campus Wellbeing Survey. [PDF]
Front Sports Act LivingDerkach L, Hou M, Wu C, Faulkner G.
europepmc +1 more source
Child pedestrian and cyclist injuries, and the built and social environment across Canadian cities: the Child Active Transportation Safety and the Environment Study (CHASE). [PDF]
Inj Prev, 2022 Rothman L +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Bay Area transportation : state of the system 2002
The Metropolitan Transportation Commission (MTC) and Caltrans District 4 have engaged in a collaborative effort to assemble key facts and performance indicators of interest to Bay Area commuters and other travelers.
California. Metropolitan Transportation Commission +1 more
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