Approach to Supporting Black Communities in Planning and Developing Pedestrian and Active Transportation Infrastructure to Improve the Built Environment. [PDF]
J Healthy Eat Act LivingCasas AD +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Active living environments mediate rural and non-rural differences in physical activity, active transportation, and screen time among adolescents. [PDF]
Prev Med Rep, 2021 Christiana RW, Bouldin ED, Battista RA.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Other title: Kansas Department of Transportation Overview Other title: KDOT Overview
, 2013 Title supplied by cataloger from file name.; "January 17, 2013.", Committee names taken from the Kansas Department of Transportation website.; Presentation to the Kansas Legislature, Joint Transportation Committees, by staff of the Kansas Department of ...
Kansas. Department of Transportation.
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The effectiveness of new urban trail infrastructure on physical activity and active transportation: a systematic review and meta-analysis of natural experiments. [PDF]
Int J Behav Nutr Phys ActFast I +5 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Other title: Kansas Department of Transportation 101
, 2018 "January 18, 2018."; Title supplied by the Kansas Department of Transportation website. Alternate title supplied by cataloger.; Presentation before the Kansas Legislature, House Committee on Transportation, by the Kansas Department of ...
Kansas. Department of Transportation.
core