Results 121 to 130 of about 158,807,029 (257)

Altered expression of activin, cripto, and follistatin in the endometrium of women with endometrioma

, 2011
Objective: To evaluate the expression pattern of activin A, activin receptors, and activin modulators messenger RNA (mRNA) in the eutopic endometrium of patients with endometriosis at different phases of the menstrual cycle and to evaluate the mRNA ...
Novembri, R., Luisi, S., Fernando M. Reis, Patrizia Carrarelli, Stefano Luisi, Rocha, A. L., Lorenzo Sabbioni, Felice Petraglia, Carrarelli, P., Sabbioni, L., Reis, F. M., Petraglia, F., Ana Luiza L. Rocha, Romina Novembri, Petraglia, Felice   +14 more
core   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Activin A plays an essential role in migration and proliferation of hepatic stellate cells via Smad3 and calcium signaling

Scientific Reports
Activin A and hepatic stellate cells (HSCs) are involved in tissue repair and fibrosis in liver injury. This study investigated the impact of activin A on HSC activation and migration.
Wei Zhang, Linjing Zhu, Fang Fang, Fenglin Zhang, Runnan Wang, Ke Yang, Yahui Liu, Xueling Cui   +7 more
doaj   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Activin A Suppresses Osteoblast Mineralization Capacity by Altering Extracellular Matrix (ECM) Composition and Impairing Matrix Vesicle (MV) Production*

Molecular & Cellular Proteomics, 2013
During bone formation, osteoblasts deposit an extracellular matrix (ECM) that is mineralized via a process involving production and secretion of highly specialized matrix vesicles (MVs).
Rodrigo D. Alves, M. Eijken, K. Bezstarosti, Jeroen A. A. Demmers, J. van Leeuwen   +4 more
semanticscholar   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Acute Modulation of Synaptic Plasticity of Pyramidal Neurons by Activin in Adult Hippocampus

Frontiers in Neural Circuits, 2014
Activin A is known as a neuroprotective factor produced upon acute excitotoxic injury of the hippocampus (in pathological states). We attempt to reveal the role of activin as a neuromodulator in the adult male hippocampus under physiological conditions ...
Yoshitaka eHasegawa, Hideo eMukai, Hideo eMukai, Hideo eMukai, Hideo eMukai, Makoto eAsashima, Yasushi eHojo, Yasushi eHojo, Yasushi eHojo, Muneki eIkeda, Yoshimasa eKomatsuzaki, Yuuki eOoishi, Suguru eKawato, Suguru eKawato, Suguru eKawato, Suguru eKawato   +15 more
doaj   +1 more source

INHBB Promotes Colorectal Cancer Progression by Inducing CD8+ T Cell Exhaustion via the ACVR2B‐SMAD Signaling Axis

Cancer Science, EarlyView.
INHBB secreted by colorectal cancer cells activates ACVR2B‐SMAD signaling to induce CD8+ T‐cell exhaustion and drive tumor progression. SB431542 blocks this oncogenic immune‐suppressive axis. ABSTRACT To investigate the expression pattern, biological functions and regulatory mechanisms of inhibin beta B (INHBB) in colorectal cancer (CRC), and to ...
Guanghui Liu, Yuanhua Liu, Hongchao Zhao, Junfeng Sun, Hongwei Yang, Qingqing Ding   +5 more
wiley   +1 more source

Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy

, 2010
Activin-A is a protein over-expressed and secreted by the brain after neuronal destruction. We evaluated whether serum activin-A increases in asphyxiated full-term newborns (AFTNs) at risk of hypoxic-ischemic-encephalopathy (HIE). 105 consecutive infants
FLORIO, P., BATTISTA, R., EL HADI ABDALLA, A., GAZZOLO, D., ABELLA, R., PINZAUTI, S., LI VOLTI, G., STRAMBI, M., GALLERI, L., FRIGIOLA, A.   +9 more
core   +1 more source

Functional Analysis of Mature Activin A Produced by Enterokinase in Plant Cells

Rice
Molecular farming for producing biopharmaceuticals in plants is considered an excellent method to replace some of the production methods currently used, and a significant number of recombinant proteins have already shown the potential to facilitate this.
Ki-Beom Moon, Ji-Sun Park, Han-Gyeul Kim, Jae-Heung Jeon, Tae-Ho Kwon, Kyung-Sook Chung, Hyo-Jun Lee, Hyun-Soon Kim   +7 more
doaj   +1 more source